Results 251 to 260 of about 31,453,429 (295)

Molecular aspects of the structures and functions of the prostaglandin E receptors

Journal of Lipid Mediators and Cell Signalling, 1996
Prostaglandin (PG) E2 exerts a variety of biological activities for the maintenance of local homeostasis in the body. The effects of PGE2 are exerted by a variety of PGE receptors which are different in their signal transduction properties and are classified into four subtypes, EP1, EP2, EP3 and EP4.
A, Ichikawa, Y, Sugimoto, M, Negishi
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Topographical distribution of prostaglandin E receptors in human myometrium

BJOG: An International Journal of Obstetrics & Gynaecology, 1988
Summary. The binding of radiolabelled prostaglandin (PG) F2α and PGE2 by human myometrium was measured in vitro and the distribution and characteristics of the binding sites in non‐pregnant and pregnant uteri were studied. PGF2α binding sites were of low affinity (Kd 30 nM) and could be occupied by PG of the E series with higher affinity than PGF2α ...
J M, Adelantado, A, López Bernal, A C, Turnbull   +2 more
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Prostaglandin E receptors as inflammatory therapeutic targets for atherosclerosis

Life Sciences, 2011
Prostaglandin E receptors (EPs) are the G-protein-coupled receptors (GPCRs) that respond to type E(2) prostaglandin (PGE(2)). Data has shown that PGE(2) may function as an endogenous anti-inflammatory mediator by suppressing the production of cytokines.
Cui, Yang, Xiuxia, Liu, Qing, Cao, Qian, Liang, Xiaohua, Qiu   +4 more
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Prostaglandin E2 as a mediator of fever: the role of prostaglandin E (EP) receptors

Frontiers in Bioscience, 2004
Prostaglandin E2 (PGE2) is a principal fever mediator that induces hyperthermia when injected into the organum vasculosum lamina terminalis (OVLT) and the adjacent preoptic area of the hypothalamus (POA). PGE (EP) receptors have four subtypes, i.e. EP1, EP2, EP3, and EP4. In the rat OVLT/POA region, at least three of these receptors, i.e. EP1, EP3, and
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Modulation of the Prostaglandin E Receptor

Obstetrics & Gynecology, 1999
To evaluate the modulatory effects of interleukin (IL)-1beta and prostaglandin (PG)E2 on the PGE2 receptor subtype EP1 in amnion cell cultures.Amnion cell cultures were incubated in increasing concentrations of (IL)-1beta or PGE2. Cultures were also incubated in high concentrations of IL-1beta and PGE2 in combination.
E P, Spaziani, W F, O'Brien, J C, Tsibris, R R, Benoit, S F, Gould   +4 more
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[11] Characterization of prostaglandin E receptor in membranes and its use in the assay of prostaglandin E

1974
Publisher Summary Prostaglandins have been implicated in the regulation of a wide variety of physiological activities including the dilation of blood vessels, the metabolism of fat, and the secretion of gastric acids. Some of the effects of prostaglandins seem to be mediated by changes in the level of cyclic AMP.
M. Smigel, J.C. Frölich, Sidney Fleischer   +2 more
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Receptors for E and F prostaglandins in airways.

Advances in prostaglandin and thromboxane research, 1980
Determination of dose/response relationships for E and F PGs in guinea pig trachea and human bronchial muscle in vitro indicates that mixed contractant and relaxant activities are present in different proportions in each PG. Further analysis of these effects, using (a) tachyphylaxis to individual PGs and (b) indomethacin as a PG antagonist, argues that
P J, Gardiner, H O, Collier
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Prostaglandin F2α regulates cytokine responses of mast cells through the receptors for prostaglandin E

Biochemical and Biophysical Research Communications, 2008
There is an increasing body of evidence that prostanoids modulate mast cell functions and contribute to the development of allergic inflammation. The present study aimed to identify an undetermined function of prostaglandin (PG) F(2alpha) in mast cell activation and the signaling mechanism involved in it.
Izumi, Kaneko, Takanori, Hishinuma, Kaori, Suzuki, Yuji, Owada, Noriko, Kitanaka, Hisatake, Kondo, Junichi, Goto, Hiroshi, Furukawa, Masao, Ono   +8 more
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Prostaglandin E receptors in myometrial cells.

Acta physiologica Hungarica, 1998
Prostaglandins (PGs) exert their effects via binding to specific cell surface receptors and influencing second messenger systems through G-proteins. PGE2 may interact with at least four receptor subtypes (EP1, EP2, EP3, EP4), each showing different pharmacological profiles.
G, Asbóth, S, Phaneuf, A L, López Bernal   +2 more
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Differential localization of prostaglandin E receptor subtypes in human kidney

American Journal of Physiology-Renal Physiology, 1996
Four prostaglandin E2 (PGE2) receptors designated EP1, EP2, EP3, and EP4 have been pharmacologically identified, cloned, and sequenced. The present studies determined the intrarenal distribution of these EP-receptor subtypes in human kidney using in situ hybridization with riboprobes for the human EP receptors.
M D, Breyer, L, Davis, H R, Jacobson, R M, Breyer   +3 more
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