Results 261 to 270 of about 31,453,429 (295)

Role of Prostaglandin E Receptor Subtypes in Gastroduodenal HCO3 - Secretion

Medicinal Chemistry, 2005
Gastroduodenal HCO3- secretion is a key process that aids in preventing acid-peptic injury. Endogenous prostaglandins (PGs) play a particularly important role in the local control of this secretion. The secretion of HCO3- in both the stomach and duodenum was increased in response to PGE2 as well as mucosal acidification, the latter occurring with ...
Koji, Takeuchi, Eitaro, Aihara, Masamune, Hayashi, Yoko, Sasaki   +3 more
openaire   +2 more sources

Characterization of prostaglandin E receptors in canine small intestine using [3H] prostaglandin E1 binding

Prostaglandins, 1992
Prostaglandin E (PGE) receptors in canine small intestinal mucosal and muscle membrane preparations were labeled with [3H] PGE1. Saturable, high affinity binding of [3H] PGE1 was observed in both preparations. The density of binding sites (fmol/mg protein) was 39 for mucosal membranes and 60 for muscle membranes, with corresponding dissociation ...
R H, Keith, B S, Tsai, P W, Collins, W E, Perkins, R L, Shone, A F, Gasiecki, R G, Bianchi, R F, Bauer   +7 more
openaire   +2 more sources

Regulation of TNFα and interleukin-10 production by prostaglandins I2 and E2: studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists

Biochemical Pharmacology, 2001
To know which receptors of prostaglandins are involved in the regulation of TNFalpha and interleukin 10 (IL-10) production, we examined the production of these cytokines in murine peritoneal macrophages stimulated with zymosan. The presence of PGE(2) or the PGI(2) analog carbacyclin in the medium reduced the TNFalpha production to one-half, whereas IL ...
S, Shinomiya, H, Naraba, A, Ueno, I, Utsunomiya, T, Maruyama, S, Ohuchida, F, Ushikubi, K, Yuki, S, Narumiya, Y, Sugimoto, A, Ichikawa, S, Oh-ishi   +11 more
openaire   +2 more sources

Prostaglandin E (EP) receptor subtypes and sleep

NeuroReport, 2000
Prostaglandin (PG) E2 reportedly augmented wakefulness when continuously infused into the third ventricle of the rat brain, whereas it promoted sleep when continuously infused into the subarachnoid space of the ventral surface zone of the rostral basal forebrain, which was designated previously as a PGD2-sensitive sleep-promoting zone (PGD2-SZ). In the
Y, Yoshida, H, Matsumura, T, Nakajima, M, Mandai, T, Urakami, K, Kuroda, H, Yoneda   +6 more
openaire   +2 more sources

Molecular Diversity of Prostanoid Receptors; Subtypes and Isoforms of Prostaglandin E Receptor

1997
cDNA cloning of PGE receptors revealed that there are at least three distinct subtypes of the receptor derived from different genes, which are different in ligand binding character and signal transduction. They also distribute differently in the body and localize in different cells of the organ. The cloning study also revealed that multiple isoforms of
openaire   +2 more sources

Prostaglandin E receptors

Journal of Lipid Mediators and Cell Signalling, 1995
M, Negishi, Y, Sugimoto, A, Ichikawa
openaire   +2 more sources

Effect of inhibitors of prostaglandin synthesis on uterine prostaglandin E receptor binding

BJOG: An International Journal of Obstetrics & Gynaecology, 1989
M C, Rees, A, López Bernal
openaire   +2 more sources

Isolation and properties of intermediates in prostaglandin biosynthesis

Lipids and Lipid Metabolism, 1973
D H Nugteren, D H Nugteren
exaly  

Prostaglandin synthase 2

Lipids and Lipid Metabolism, 1996
H R Herschman
exaly  

Metabolism of prostaglandin E1 and of glutathione conjugate of prostaglandin A1 (GSH-prostaglandin A1) by prostaglandin 9-ketoreductase from rabbit kidney

Lipids and Lipid Metabolism, 1979
Harald S Hansen
exaly