Results 151 to 160 of about 35,200 (265)

P2X7 Receptor Modulation of Visual Responses in the Retina

, 2015
Adenosine 5’ triphosphate (ATP)-gated P2X7 receptors (P2X7Rs) are known to act as conduits for photoreceptor and retinal ganglion cell (RGC) damage, consequences of various neurodegenerative conditions within the visual pathway. Growing evidence supports
Chavda, S
core  

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, Volume 45, Issue 5, Page 929-936, June 2026.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Purinergic Receptor [PDF]

, 2020
openaire   +1 more source

Clopidogrel, an ADP‐P2Y12 Receptor Antagonist, Is Associated With Lower Opioid Consumption and a Reduced Incidence of Delirium in Cancer Patients Receiving Chemotherapy: A Nationwide Retrospective Cohort Study in Japan

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Clopidogrel use was associated with reduced opioid consumption, lower use of other analgesics, and a decreased incidence of hyperactive delirium compared with aspirin in cancer patients receiving chemotherapy, suggesting a potential analgesic effect possibly linked to P2Y12 receptor inhibition.
Hiroaki Abe, Reo Inoue, Takamichi Kogure, Rikuhei Tsuchida, Hiroaki Owada, Yoshika Sudo, Yaeko Yokoshima, Hiroki Matsui, Hideo Yasunaga, Masahiko Sumitani   +9 more
wiley   +1 more source

Nucleotide signaling in neutrophils: a key player in cancer dynamics. [PDF]

Purinergic Signal
da Silva JLG, Sévigny J, Leal DBR.
europepmc   +1 more source

G Protein‐Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models

Obesity, Volume 34, Issue S1, Page 77-87, June 2026.
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Xun Sun, Connor Mahler, Natalie D. Stull, Ali Nasiri, Baohua Zhou, Varman Samuel, Gerald Shulman, Jonathan N. Flak, Hongxia Ren   +8 more
wiley   +1 more source

Channeling teamwork: ATP and lipids cooperate to gate P2X receptors. [PDF]

Sci Adv
Bosmans F, Kawate T.
europepmc   +1 more source

P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents

, 1998
The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE, Brown, DA, Barnard, EA, Filippov, AK   +3 more
core  

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors. [PDF]

Purinergic Signal
Allum E, Stokes L.
europepmc   +1 more source