Results 151 to 160 of about 5,101 (183)
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Glia, 2012
AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi +3 more
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AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi +3 more
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P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes
Journal of Applied Physiology, 1989Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
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Biochemical and Biophysical Research Communications, 1994
Genistein, a potent inhibitor for protein tyrosine kinase, remarkably inhibited the stimulatory action of N6-(L-2-phenylisopropyl)adenosine (PIA), an A1-adenosine receptor agonist, on thyrotropin (TSH)-induced phospholipase C activation in FRTL-5 thyroid cells.
F, Okajima +5 more
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Genistein, a potent inhibitor for protein tyrosine kinase, remarkably inhibited the stimulatory action of N6-(L-2-phenylisopropyl)adenosine (PIA), an A1-adenosine receptor agonist, on thyrotropin (TSH)-induced phospholipase C activation in FRTL-5 thyroid cells.
F, Okajima +5 more
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On the purinergic system in rat duodenum : existence of P1and P2receptors on the smooth muscle
Archives Internationales de Physiologie et de Biochimie, 1990In rat duodenum, in vitro, in the presence of atropine and guanethidine, ATP administration caused a tetrodotoxin-insensitive relaxation followed by a rebound contraction. A similar response was obtained also after electrical field stimulation (EFS) of non-adrenergic, non-cholinergic (NANC) nerves.
A, Postorino, R, Serio, F, Mulè
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PharmaNutrition, 2019
Abstract Cross-talk between hypertension and diabetes associated with red wine consumption triggering cardioprotective and antihypertensive effects have been well established; nevertheless, the role of isolated total polyphenols from extracts of Vitis vinifera grape skin (ACH09) and the possible correlation with cardiovascular functionality mediated ...
Guilherme Henrique Souza Bomfim +6 more
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Abstract Cross-talk between hypertension and diabetes associated with red wine consumption triggering cardioprotective and antihypertensive effects have been well established; nevertheless, the role of isolated total polyphenols from extracts of Vitis vinifera grape skin (ACH09) and the possible correlation with cardiovascular functionality mediated ...
Guilherme Henrique Souza Bomfim +6 more
openaire +1 more source
P1-/P2-purinergic receptors on cultured rabbit retinal Müller cells.
Japanese journal of ophthalmology, 1998Adenosine 5'-triphosphate (ATP) and its metabolic products function as neurotransmitters or neuromodulators under the control of P1/P2-purinergic receptors. To determine the presence of these receptors on retinal Müller cells, spectrofluorometry was carried out on intracellular calcium mobilization, using Fura-2 images.
Y, Liu, M, Wakakura
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Role of P1 and P2 purinergic receptors in the dentate gyrus during in vitro ischemia
2015The hippocampus is comprised of two distinct subfields that show different responses to hypoxic/ischemic brain injury: the CA1 region is particularly susceptible, whereas the dentate gyrus (DG) is quite resistant. A major resistance of the DG to ischemia in adulthood is probably due to the regenerative capacity of the neural stem cells of the ...
PUGLIESE, ANNA MARIA +7 more
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2015
The hippocampus is comprised of two distinct subfields that show different responses to hypoxic/ischemic brain injury: the CA1 region is particularly susceptible, whereas the dentate gyrus (DG) is quite resistant. A major resistance of the DG to ischemia in adulthood is probably due to the regenerative capacity of the neural stem cells of the ...
COPPI, ELISABETTA +4 more
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The hippocampus is comprised of two distinct subfields that show different responses to hypoxic/ischemic brain injury: the CA1 region is particularly susceptible, whereas the dentate gyrus (DG) is quite resistant. A major resistance of the DG to ischemia in adulthood is probably due to the regenerative capacity of the neural stem cells of the ...
COPPI, ELISABETTA +4 more
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Synthesis and Characterization of New Ligands for the Purinergic P1 Receptors
2010Adenosine (Ado) is a naturally occurring nucleoside, involved in the regulation of many physiological and pathophysiological processes through the activation of four specific cell membrane receptors (AA1R, AA2AR, AA2BR, and AA3R), which belong to the superfamily of G protein-coupled receptors. Ado receptors (ARs) are responsible for the wide variety of
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Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies
Drug Resistance Updates, 2023Yih-Cherng Liou +2 more
exaly