Results 51 to 60 of about 5,101 (183)
Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]
, 2007 Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core
Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function [PDF]
, 2011 Extracellular purines and pyrimidines have emerged as key regulators of a wide range of physiological and pathophysiological cellular processes acting through P1 and P2 cell surface receptors.
Katz, Sebastian +5 more
core +1 more source
Purinergic Receptors in Ocular Inflammation
Mediators of Inflammation, 2014 Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
Ana Guzman-Aranguez +3 more
doaj +1 more source
Role of adenosine A2a receptor in cancers and autoimmune diseases
Immunity, Inflammation and Disease, 2023 Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine.
Hongling Ye +5 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim +6 more
wiley +1 more source
An emerging role for adenosine and its receptors in bone homeostasis
Frontiers in Endocrinology, 2012 Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans +3 more
doaj +1 more source
Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization
International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 4, April 2026.We present a novel DEC approach for calculating RBC shapes applicable to other cell types and membrane problems. We derive an energy minimization equation that can be solved semi‐implicitly, and a Lie derivative method to control node spacing. This novel work should aid computational modeling in many biological situations.
Keith C. Afas, Daniel Goldman
wiley +1 more source
Control of Gut Inflammation by Modulation of Purinergic Signaling
Frontiers in Immunology, 2020 Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often
Marta Vuerich +4 more
doaj +1 more source
Adenosine pathway regulates inflammation during Plasmodium vivax infection
Frontiers in Immunology, 2023 BackgroundPlasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria.
Suelen Queiroz Diniz +15 more
doaj +1 more source
Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov +4 more
wiley +1 more source