Results 61 to 70 of about 4,839 (156)

Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells

The Journal of Toxicological Sciences
Purinergic signaling plays an important role in vascular biology by vascular tone, inflammation, and remodeling through extracellular nucleotides that activate the P1 and P2 receptors. However, the expression patterns of these receptors in commonly used vascular cell models are not well characterized.
Ikeuchi, Lihito, Hara, Takato, Kitabatake, Kazuki, Uchiumi, Fumiaki, Yamamoto, Chika, Tsukimoto, Mitsutoshi, Fujie, Tomoya, Kaji, Toshiyuki   +7 more
openaire   +2 more sources

Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov, Ganna V. Sotkis, Semen I. Yelyashov, Valeri G. Naidenov, Yaroslav M. Shuba   +4 more
wiley   +1 more source

Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

Frontiers in Immunology, 2017
Cancer is still one of the world’s most pressing health-care challenges, leading to a high number of deaths worldwide. Immunotherapy is a new developing therapy that boosts patient’s immune system to fight cancer by modifying tumor–immune cells ...
Paola de Andrade Mello, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +2 more
doaj   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Expression and distribution of ectonucleotidases in mouse urinary bladder.

PLoS ONE, 2011
BackgroundNormal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling is ATP.
Weiqun Yu, Simon C Robson, Warren G Hill
doaj   +1 more source

The role of purinergic receptors in stem cell differentiation

Computational and Structural Biotechnology Journal, 2015
A major challenge modern society has to face is the increasing need for tissue regeneration due to degenerative diseases or tumors, but also accidents or warlike conflicts.
Constanze Kaebisch, Dorothee Schipper, Patrick Babczyk, Edda Tobiasch   +3 more
doaj   +1 more source

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity

Frontiers in Pharmacology, 2018
Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+) are released as danger signals from cells during infection and sterile inflammation.
Stephan Menzel, Nicole Schwarz, Friedrich Haag, Friedrich Koch-Nolte   +3 more
doaj   +1 more source

Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids

Frontiers in Pharmacology, 2018
Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential ...
Zhichao Zhou, Zhichao Zhou, Zhichao Zhou, Inge M. Lankhuizen, Inge M. Lankhuizen, Heleen M. van Beusekom, Heleen M. van Beusekom, Caroline Cheng, Caroline Cheng, Caroline Cheng, Dirk J. Duncker, Dirk J. Duncker, Daphne Merkus, Daphne Merkus   +13 more
doaj   +1 more source

Purinergic enzymes on extracellular vesicles: immune modulation on the go

Frontiers in Immunology
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti ...
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Felix Schoppmeier, Filippo Cortesi, Filippo Cortesi, Nicola Gagliani, Nicola Gagliani, Eva Tolosa   +8 more
doaj   +1 more source