Results 61 to 70 of about 5,101 (183)
P2X and P2Y receptor signaling in red blood cells
Frontiers in Molecular Biosciences, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter +2 more
doaj +1 more source
Purinergic regulation: From a risky hypothesis to a triumphant theory [PDF]
, 2021 With the discovery of the ATP structure in 1929, significant progress was made in understanding the role of nucleosides and nucleotides in the body.
Serebryanaya, Natalia B. +1 more
core +1 more source
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Neural Regeneration ResearchPurinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss +2 more
doaj +1 more source
Astrocyte Regulation of Spinal Circuit Function
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
wiley +1 more source
NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia [PDF]
, 2018 The movement of microglia is regulated mainly by P1 and P2 purinergic receptors, which are activated by various nucleotides and their metabolites.
이민구, 김주영
core +1 more source
Who Is Who in Adenosine Transport
Frontiers in Pharmacology, 2018 Extracellular adenosine concentrations are regulated by a panel of membrane transporters which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two gene families encoding Equilibrative and Concentrative Nucleoside ...
Marçal Pastor-Anglada +3 more
doaj +1 more source
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, Volume 59, Issue 1, January 2026.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source
Purinergic signaling in kidney disease [PDF]
, 2016 Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals.
Unwin, RJ +8 more
core +1 more source
Development of the neurohypophysis: A major neuroendocrine interface
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh +5 more
wiley +1 more source
Modulators of Ion Transport in Nasal Polyps: An Measurement of Short-Circuit Current [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesTo examine possible modulators of the ion transport through the apical membrane of the nasal polyps.MethodsThe study was conducted using the freshly-excised nasal polyps from the patients with chronic sinusitis.
Jun Ho Lee +3 more
doaj +1 more source