Results 61 to 70 of about 8,556 (198)

Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov, Ganna V. Sotkis, Semen I. Yelyashov, Valeri G. Naidenov, Yaroslav M. Shuba   +4 more
wiley   +1 more source

Control of Gut Inflammation by Modulation of Purinergic Signaling

Frontiers in Immunology, 2020
Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often
Marta Vuerich, Samiran Mukherjee, Simon C. Robson, Simon C. Robson, Maria Serena Longhi   +4 more
doaj   +1 more source

Adenosine pathway regulates inflammation during Plasmodium vivax infection

Frontiers in Immunology, 2023
BackgroundPlasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria.
Suelen Queiroz Diniz, Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhélio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli, Lis Ribeiro Antonelli   +15 more
doaj   +1 more source

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade. [PDF]

, 2016
Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in ...
Allaman, I., Fiumelli, H., Jourdain, P., Magistretti, P.J., Marquet, P., Rothenfusser, K.   +5 more
core   +2 more sources

P2X and P2Y receptor signaling in red blood cells

Frontiers in Molecular Biosciences, 2015
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +2 more
doaj   +1 more source

Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]

, 2017
Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core  

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss, Christine Heuer, Marina Herwerth   +2 more
doaj   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source