Results 81 to 90 of about 5,101 (183)

Purinergic Signaling in Health and Disease

, 2020
Adenosine 5’-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy “currency.” After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a ...

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Purinergic signaling in atherosclerosis

, 2015
Cell surface expression of specific receptors and ectonucleotidases makes extracellular nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for physiological and pathological events, including tissue stress and damage. Recent
Idzko M, la Sala A., Vitiello L, FERRARI, Davide   +3 more
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Purinergic signaling, DAMPs, and inflammation

, 2020
Danger sensing is one of the most fundamental evolutionary features enabling multicellular organisms to perceive potential threats, escape from risky situations, fight actual intruders, and repair damage.
Sarti A. C., Di Virgilio F., Coutinho-Silva R.   +2 more
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Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Claire M. Peppiatt-Wildman, Scott-Ward, Toby S., Alberto Contreras-Sanz, Kevin M. G. Taylor, Malone-Lee, James, Wildman, Scott S.P., Rebecca E. Birch, Scott S. P. Wildman, James Malone-Lee, Jennifer C. Jacoby, Taylor, Kevin M. G., Gill, Hardyal S., Peppiatt-Wildman, Claire M., Birch, Rebecca E., Contreras-Sanz, Alberto, Hardyal S. Gill, Toby S. Scott-Ward, Jacoby, Jennifer C., Wildman, Scott S. P.   +18 more
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Experimental documentation of presence of purinergic receptors at human atria.

, 1986
Our experimental data suggest the likelihood that there is a purinergic inhibition on human atria; it appears that inhibition is mediated via P1/Ri (A-1/Ri) and P-2 receptors.
C. Matera, R. Acampora, FILIPPELLI, Amelia, S. Soreca, D. Iarussi, E. Lampa, G. Tortora, E. Marmo   +7 more
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Purinergic signaling

, 2012
The concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5′-triphosphate (ATP) was a transmitter in non-adrenergic, non-cholinergic inhibitory nerves in the guinea pig taenia coli.
Burnstock, G., Verkhratsky, A.; id_orcid
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Post-weaning social isolation impairs purinergic signaling in rat brain.

, 2021
Early life stressors, such as social isolation (SI), can disrupt brain development contributing to behavioral and neurochemical alterations in adulthood.
Moritz, Cesar Eduardo Jacintho, Andrejew, Roberta, Paim, Milla, Almeida, Roberto Farina de, Carreño, Fernando, Rates, Stela Maris Kuze, Battastini, Maria Oliveira, Souza, Diogo Onofre, Elisabetsky, Elaine   +8 more
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Expression and distribution of ectonucleotidases in mouse urinary bladder.

PLoS ONE, 2011
BackgroundNormal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling is ATP.
Weiqun Yu, Simon C Robson, Warren G Hill
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Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile

, 2021
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype.
Zur Mühlen, Constantin von, Hertle, L., Zirlik, A., Garlen, Sunaina von, Bode, C., Hilgendorf, I., Hilgendorf, Inken, Wolf, D., Nettesheim, A., Saller, Benedikt S., Schäfer, Ibrahim, Bulatova, Kseniya, von Garlen, S., Merz, Julian, Bode, Christoph, König, S., Bulatova, K., Karnbrock, Lorenz, von zur Mühlen, C., Wolf, Dennis, Hoppe, Natalie, Peikert, A., Karnbrock, L., Engelmann, J., Dimanski, D., Albrecht, P., Saller, B. S., Hoppe, N., Engelmann, Juliane, Groß, O., Zirlik, Andreas, Groß, Olaf, Schäfer, I., Dimanski, Daniel, Albrecht, Philipp, Stachon, Peter, Merz, J., Peikert, Alexander   +37 more
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The purinergic system in allotransplantation

, 2014
The purine nucleotide adenosine triphosphate (ATP) is a universal source of energy for any intracellular reaction. Under specific physiological or pathological conditions, ATP can be released into extracellular spaces, where it binds and activates the ...
S. Tezza, G. Visner, P. Fiorina, C. Fotino, A. Vergani, A. Pileggi, A. Chandraker   +6 more
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