Results 71 to 80 of about 5,101 (183)

Mesenchymal Stem Cells Restore Endometrial Integrity and Sustain Pregnancy via CCR7‐ERK/JNK Signaling Modulation

Stem Cells International, Volume 2026, Issue 1, 2026.
Recurrent pregnancy loss (RPL), defined as more than two consecutive miscarriages before 20 weeks of gestation, affects 1%–5% of reproductive‐aged women, with nearly half of the cases remaining idiopathic. Using ethanol‐induced endometrial injury in rats to simulate RPL, we demonstrated that mesenchymal stem cells (MSCs) exert therapeutic effects ...
Yunguo Lei, Juanmei Gao, Ning Zhang, Yunjun Lin, Weihua Yang, Yuequn Chen, Qiang Wei, Jianmei Xia, Harleen Khatra   +8 more
wiley   +1 more source

NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. [PDF]

PLoS ONE, 2013
Purinergic receptor expression and involvement in steroidogenesis were examined in NCI-H295R (H295R), a human adrenal cortex cell line which expresses all the key enzymes necessary for steroidogenesis. mRNA/protein for multiple P1 (A(2A) and A(2B)), P2X (
Haruhisa Nishi, Hirokazu Arai, Toshihiko Momiyama   +2 more
doaj   +1 more source

Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells

The Journal of Toxicological Sciences
Purinergic signaling plays an important role in vascular biology by vascular tone, inflammation, and remodeling through extracellular nucleotides that activate the P1 and P2 receptors. However, the expression patterns of these receptors in commonly used vascular cell models are not well characterized.
Lihito, Ikeuchi, Takato, Hara, Kazuki, Kitabatake, Fumiaki, Uchiumi, Chika, Yamamoto, Mitsutoshi, Tsukimoto, Tomoya, Fujie, Toshiyuki, Kaji   +7 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Adrenergic receptor activation involves ATP release and feedback through purinergic receptors

, 2010
Formyl peptide receptor-induced chemotaxis of neutrophils depends on the release of ATP and autocrine feedback through purinergic receptors. Here, we show that adrenergic receptor signaling requires similar purinergic feedback mechanisms.
Tobias Woehrle, Yuka Sumi, Wolfgang G. Junger, Yu Chen, Yongli Yao, Andrew Li   +5 more
core   +1 more source

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Frontiers in Cellular Neuroscience, 2019
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary ...
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk   +13 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, Volume 599, Issue 22, Page 3208-3243, November 2025.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

Frontiers in Immunology, 2017
Cancer is still one of the world’s most pressing health-care challenges, leading to a high number of deaths worldwide. Immunotherapy is a new developing therapy that boosts patient’s immune system to fight cancer by modifying tumor–immune cells ...
Paola de Andrade Mello, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +2 more
doaj   +1 more source

Comprehensive Genome‐Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases

Brain and Behavior, Volume 15, Issue 11, November 2025.
GI and ND GWAS and blood eQTL data were analyzed using LDSC, HDL, LAVA, GPA, PLACO, FUMA, MAGMA, SMR, HEIDI, and two‐sample MR to assess genetic correlations, pleiotropy, functional annotation, shared gene expression, and causal relationships. ABSTRACT Background This study investigates the shared genetic basis between gastrointestinal (GI) diseases ...
Yan Jiang, Yuxiang Zhang, Lei Ma, Chao Li   +3 more
wiley   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source