Results 71 to 80 of about 681,545 (189)
An emerging role for adenosine and its receptors in bone homeostasis
Frontiers in Endocrinology, 2012 Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans +3 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues +8 more
wiley +1 more source
Metabotropic purinergic receptors in lipid membrane microdomains
, 2013 There is broad evidence that association of transmembrane receptors and signalling molecules with lipid rafts/caveolae provides an enriched environment for protein-protein interactions necessary for signal transduction, and a mechanism for the modulation
D' Ambrosi, N, Volonte, C
core +4 more sources
Control of Gut Inflammation by Modulation of Purinergic Signaling
Frontiers in Immunology, 2020 Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often
Marta Vuerich +4 more
doaj +1 more source
Adenosine pathway regulates inflammation during Plasmodium vivax infection
Frontiers in Immunology, 2023 BackgroundPlasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria.
Suelen Queiroz Diniz +15 more
doaj +1 more source
Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange +4 more
wiley +1 more source
P2X and P2Y receptor signaling in red blood cells
Frontiers in Molecular Biosciences, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter +2 more
doaj +1 more source
Nucleotide Metabolism in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Neural Regeneration ResearchPurinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss +2 more
doaj +1 more source