Results 161 to 170 of about 577,314 (185)

Sensory Purinergic Receptor P2X3 Is Elevated in Burning Mouth Syndrome

International Journal of Oral and Maxillofacial Surgery, 2010
Recent studies show that P2X(3) may play a role in neuropathic pain, including orofacial pain. Burning mouth syndrome (BMS) is a chronic neuropathic pain condition affecting 0.6-12% of post-menopausal women in the Western world. This study evaluates, for the first time, P2X(3) immunoreactivity levels in lingual mucosa in BMS patients.
Tara Renton, Yiangos Yiangou, Praveen Anand   +2 more
exaly   +4 more sources

Roles of Ectodomain and Transmembrane Regions in Ethanol and Agonist Action in Purinergic P2X2 and P2X3 Receptors [PDF]

Neuropharmacology, 2008
The present work investigated sites of ethanol action in ATP-gated P2X receptors (P2XRs) using chimeric strategies that exploited the differences in ethanol response between P2X2R (inhibition) and P2X3R (potentiation). We tested ethanol (10-200mM) effects on ATP- and alpha,beta-methylene-ATP (alpha,beta-meATP)-induced currents in wildtype P2X2, P2X3 ...
Liana Asatryan, John J Woodward, Daryl L. Davies   +2 more
exaly   +3 more sources

Binding thermodynamic characterization of human P2X1 and P2X3 purinergic receptors

Biochemical Pharmacology, 2008
The present study was designed to perform binding and thermodynamic characterization of human P2X1 and P2X3 purinergic receptors expressed in HEK 293 cells. The thermodynamic parameters DeltaG degrees , DeltaH degrees and DeltaS degrees (standard free energy, enthalpy and entropy) of the binding equilibrium of well-known purinergic agonists and ...
VARANI, Katia, Surprenant A., VINCENZI, Fabrizio, TOSI, ALICE, GESSI, Stefania, MERIGHI, Stefania, BOREA, Pier Andrea   +6 more
openaire   +4 more sources

Inhibition of Urothelial P2X3 Receptors Prevents Desensitization of Purinergic Detrusor Contractions in the Rat Bladder

BJU International, 2015
Objectives To evaluate whether P2X3 receptors (P2X3R) are expressed in the bladder urothelium and to determine their possible function in modulating purinergic detrusor contractions in the rat urinary bladder. Materials and Methods
Alvaro Muñoz, Timothy B Boone
exaly   +3 more sources

Modulation of Bladder Afferent Signals in Normal and Spinal Cord-Injured Rats by Purinergic P2X3 and P2X2/3 Receptors [PDF]

BJU International, 2012
What's known on the subject? and What does the study add? It is well known that urinary bladder sensation requires the activation by ATP of ionotropic purinergic P2X3/P2X2/3 receptors located in bladder afferent C‐fibres. Furthermore, in rat models
Timothy B Boone, Alvaro Munoz, George T Somogyi   +2 more
exaly   +3 more sources

The Purinergic Receptor P2X3 Promotes Facial Pain by Activating Neurons and Cytokines in the Trigeminal Ganglion

International Immunopharmacology
The mechanism underlying allodynia/hyperalgesia caused by dental pulpitis has remained enigmatic. This investigation endeavored to characterize the influence of the purinergic receptor P2X3 on pain caused by experimental pulpitis and the mechanism involved.
Yangxi, Chen, Liangyu, Chen, Tuo, Ji, Yuan, Yu, Tiejun, Zhang, Li, Wang   +5 more
exaly   +3 more sources

Upregulation of the Purinergic Receptor Subtype P2X3 in the Trigeminal Ganglion Is Involved in Orofacial Pain Induced by Occlusal Interference in Rats

Journal of Oral & Facial Pain and Headache, 2016
To evaluate whether the purinergic receptor subtype P2X3 (P2X3R) in trigeminal ganglion (TG) neurons is involved in hyperalgesia of the temporomandibular joints (TMJs) and masseter muscles associated with placement of an occlusal interference.Forty-five rats were randomized into five groups (ie, for days 1, 3, 7, 14, or 28; nine rats per group).
Dong, Qi, Yingying, Yang, Ping, Ji, Jingjing, Kong, Qingting, Wu, Huiling, Si   +5 more
openaire   +2 more sources

Intraganglionic laminar endings in the rat esophagus contain purinergic P2X 2 and P2X 3 receptor immunoreactivity

Anatomy and Embryology, 2003
Intraganglionic laminar endings (IGLEs) represent the most prominent vagal afferent terminal structures throughout the gastrointestinal tract. They are most prominent in the esophagus and stomach, but can be found down to the distal colon. Their role as mechanosensors as proposed on anatomical grounds was recently substantiated in elegant functional ...
Z-J, Wang, W L, Neuhuber
openaire   +2 more sources

Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

Biochemical Pharmacology
Patients with epilepsy require improved medications. Purinergic receptors were identified as late as 1976 and are slowly emerging as potential drug targets for the discovery of antiseizure medications. While compounds interacting with these receptors have been approved for use as medicines (e.g., gefapixant for cough) and continue to be explored for a ...
Jeffrey M, Witkin, Hana, Shafique, Jodi L, Smith, Rok, Cerne   +3 more
openaire   +2 more sources

Evidence for P2X3, P2X4, P2X5 but not for P2X7 containing purinergic receptors in Müller cells of the rat retina

Molecular Brain Research, 2000
P2X receptors are ligand-gated ion channels activated by ATP. They are expressed in a broad variety of tissues. To date, eight P2X receptor subunits (P2X(1)-P2X(7), P2XM) have been cloned. In spite of the considerable evidence of signaling by extracellular nucleotides in other sensory systems, only few studies have been undertaken in the retina.
R, Jabs, E, Guenther, K, Marquordt, T H, Wheeler-Schilling   +3 more
openaire   +2 more sources