Results 1 to 10 of about 101,003 (237)
Retinoic Acid and Retinoid X Receptors
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Schubert, Michael, Germain, Pierre
openaire +3 more sources
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. [PDF]
Proceedings of the National Academy of Sciences, 1993 The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid nuclear receptors, RA receptor (RARs) and retinoid X receptors (RXRs), was characterized using nucleosol preparations from transiently transfected COS-1 cells. Among several stereoisomers of RA tested, including 7-cis-, 9-cis-, 11-cis-, 13-cis-, and all-trans-RA,
Philippe Kastner +9 more
openaire +3 more sources
Antagonism between retinoic acid receptors. [PDF]
Molecular and Cellular Biology, 1991 In the developing mouse, retinoic acid receptors (RARs) beta and gamma 1 are expressed in characteristic spatiotemporal patterns which are correlated with different developmental fates of the respective tissues. Understanding the cues that regulate the expression of the various RARs may therefore provide insights into the process of tissue ...
Matthias Husmann +5 more
openaire +3 more sources
A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter [PDF]
Molecular Endocrinology, 1990 The morphogen retinoic acid (RA) regulates gene transcription by interacting with specific nuclear receptors that recognize DNA sequences near responsive promoters. While much has recently been learned about the nuclear receptor proteins, little is known about the genes that are directly regulated by RA and their cis-acting response elements recognized
Magnus Pfahl +6 more
openaire +3 more sources
Retinoic Acid Receptors and Cancer [PDF]
The Journal of Nutrition, 2002 Retinoids have been shown to inhibit the growth of many human tumor cells. Although the exact molecular mechanism of retinoid-mediated growth suppression remains known, the importance of the retinoic acid receptors (RARs) and retinoid X receptors (RXRs) has been in established a number of tumor cell models.
Dianne Robert Soprano +1 more
openaire +2 more sources
The negative side of retinoic acid receptors [PDF]
Neurotoxicology and Teratology, 2011 This is a review of research that supports a hypothesis regarding early restriction of gene expression in the vertebrate embryo. We hypothesize that vertebrate retinoic acid receptors (RARs for several vertebrates but rars for zebrafish) are part of an embryonic, epigenetic switch whose default position, at the time of fertilization is "OFF".
Laura Mackey +3 more
openaire +3 more sources
Activation of Retinoic Acid Receptors by Dihydroretinoids [PDF]
Molecular Pharmacology, 2009 Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number of genes. Stereospecific saturation of the C(13)-C(14) double bond of all-trans-retinol by the enzyme, retinol saturase (RetSat), leads to the production of (R)-all-trans-13,14-dihydroretinol.
Johannes von Lintig +8 more
openaire +3 more sources
The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes [PDF]
, 2014 Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation.
Alison M. Urvalek +2 more
openaire +3 more sources
Neofunctionalization in Vertebrates: The Example of Retinoic Acid Receptors [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies. Data on evolutionary changes in gene expression (i.e., evolution of transcription factor-cis-regulatory elements relationships) tell only part of the story; protein function, best studied by ...
Escriva, Hector +9 more
openaire +9 more sources
The Corepressor CTBP2 Is a Coactivator of Retinoic Acid Receptor/Retinoid X Receptor in Retinoic Acid Signaling [PDF]
Molecular and Cellular Biology, 2013 Retinoids play key roles in development, differentiation, and homeostasis through regulation of specific target genes by the retinoic acid receptor/retinoid X receptor (RAR/RXR) nuclear receptor complex. Corepressors and coactivators contribute to its transcriptional control by creating the appropriate chromatin environment, but the precise composition
Lorenza Mittempergher +8 more
openaire +3 more sources