Results 141 to 150 of about 101,003 (237)

Therapeutic targeting of TGF‐β in lung cancer

The FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi, Amir Barzegar Behrooz, Marco Cordani, Niloufar Rahiman, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Stephen Pistorius, Seyedeh Hoda Alavizadeh, Nima Taefehshokr, Saeid Ghavami   +9 more
wiley   +1 more source

Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling. [PDF]

NPJ Breast Cancer
Huang XX, Ng LM, Lee PH, Guan P, Chow MJ, Bashir ABM, Lau M, Tan KYS, Li Z, Chan JY, Hong JH, Ng SR, Ko TK, Heng HL, Teo HL, Rhodes D, Tan P, Tan PH, McDonnell DP, Teh BT.   +19 more
europepmc   +1 more source

A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma7

Nucleic Acids Research, 1993
Lubing Zhou, Jesse Chung Sean Pang, Donald G. Munroe, Catherine Y. Lau   +3 more
openaire   +4 more sources

What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses

The FEBS Journal, Volume 292, Issue 8, Page 1853-1867, April 2025.
In this state‐of‐the‐art review, we describe how DNA‐ and RNA‐binding proteins (DRBPs) may bind both DNA and RNA and discuss the putative functional relevance of this dual binding. Furthermore, we perform an exploratory analysis into protein domains that are associated with DRBPs.
Kaspar Bresser, Branka Popović, Monika C. Wolkers   +2 more
wiley   +1 more source

Retinoic acid receptor-β deletion in a model of early pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. [PDF]

Am J Cancer Res
Mere Del Aguila E, Tang XH, Gudas LJ.
europepmc   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules. [PDF]

Immun Inflamm Dis
Sharma M, Wagh P, Shinde T, Trimbake D, Tripathy AS.   +4 more
europepmc   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Metabolomic analysis of rat arterial serum under hypobaric hypoxia: Adaptive regulation of physiological systems by metabolic reprogramming. [PDF]

Biochem Biophys Rep
Ma D, Li B, Xin B, Xie B, Zhu E, Zhang Z, Ha X.   +6 more
europepmc   +1 more source

Associations of serum carotenoids with cardiovascular disease mortality among patients with metabolic dysfunction‐associated steatotic liver disease

Hepatology Research, EarlyView.
In metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis patients aged <60 years, high serum β‐cryptoxanthin concentrations were inversely associated with CVD mortality. Abstract Aim High cardiovascular disease (CVD) mortality occurred among metabolic dysfunction‐associated steatotic liver disease ...
Qian‐Qian Wang, Jing Zhu, Lin‐Jun Miao, Si‐Ang Lv, Guo‐Yin Shen, Jun Wu   +5 more
wiley   +1 more source