Results 161 to 170 of about 62,881 (303)

Variation in the Circulating Levels of Retinoic Acid and Type 2 Diabetes: Relationships with Glycemic Control Indices, Disease Treatment and Complications. [PDF]

Diagnostics (Basel)
Alsaidan AA, Alomair BM, Almaeen AH, Aldirbas JMQ, Alanazi BRS, Algaed RHS, Alruwaili AFB, Alruwaili NMS, Aljbab DFA, Alenzi LAA, Albalawi RSS, Mohamed AA, El-Metwally TH.   +12 more
europepmc   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

ATRA-mediated RAR-α activation attenuates acrylamide-induced testicular toxicity. [PDF]

Sci Rep
Mokhlis HA, Rashed MH, Saleh IG, Eldeib MG, El-Husseiny AA, Khidr EG, Gomaa MH, Gad HS, Elnagar MR, Mokhtar MM, Aglan A.   +10 more
europepmc   +1 more source

Retinoic Acid Receptor [PDF]

, 2020
openaire   +1 more source

EXPRESSION OF A DOMINANT-NEGATIVE RETINOIC ACID RECEPTOR-GAMMA IN XENOPUS EMBRYOS LEADS TO PARTIAL RESISTANCE TO RETINOIC ACID

The administration of the teratogen retinoic acid (and other retinoids) to vertebrate embryos causes a range of developmental abnormalities. It remains to be shown how these teratogenic effects are mediated, and whether or not they reflect any ...

core  

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Maternal obesity remodels nutrient transport transcriptional programs in early mouse embryonic and extraembryonic cell lineages. [PDF]

Mol Metab
Caballero A, Chi L, Delgado-Olguín P.
europepmc   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Flipping the script: Using mucosal immune obstacles to inform vaccine design. [PDF]

PLoS Pathog
Antia A, Ding S.
europepmc   +1 more source

Cellular retinoid binding proteins and nuclear retinoic acid receptors in endometrial epithelial cells

Retinoic acid, one of the most potent of the naturally occurring retinoids (retinol and derivatives), is required in vivo for the maintenance of epithelial cell growth.
Dunlop W, Loughney AD, Siddiqui NA, Redfern CPF, Thomas EJ   +4 more
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