Results 11 to 20 of about 105,063 (283)
Retinoic Acid and Retinoid X Receptors
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
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Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva +9 more
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Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth [PDF]
Current Issues in Molecular BiologyTazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ.
Chun-Hua Wang, Lu-Kai Wang, Fu-Ming Tsai
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Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis
Biomolecules, 2022 Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
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Frontiers in Oncology, 2023 Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear
Wenjing Ding +13 more
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Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]
, 2020 This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
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Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
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Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
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Discover Oncology, 2023 TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong +5 more
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Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl +11 more
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