Results 201 to 210 of about 3,042,168 (292)

The CRABP2–MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1163-1182, October 2026.
ABSTRACT Lung cancer is the leading cause of cancer‐related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable.
Jingshun Zhang, Cui Zhang, Guopeng Jiang, Xia Liu, Yifan Li, Fuman Wang, Xuefei Sun, Peidao Sun   +7 more
wiley   +1 more source

Targeting nuclear receptors in muscular dystrophies and regenerative myogenesis. [PDF]

Front Cell Dev Biol
Mann E, Vu H, Narkar VA, Liu Y.
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Differential regulation of retinoic acid metabolism in Fanconi anemia. [PDF]

Sci Rep
Blaize JL, Noori BM, Hunter KP, Henrikson KA, Atoyan JA, Ardito AA, Chapdelaine AG, Sun G, Donovan FX, Chandrasekharappa SC, Schindler D, Howlett NG.   +11 more
europepmc   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT state. [PDF]

Proc Natl Acad Sci U S A
Bainbridge RE, Jefferson WN, Wang T, Grimm SA, Williams CJ.   +4 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Whole-genome resequencing with multidimensional annotation revealed pathogenic networks in sirenomelia. [PDF]

Ital J Pediatr
Zhu Z, Hao W, Wan Z, Ma T, Xu Y, Wang Y, Gu W.   +6 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, Volume 20, Issue 9, Page 2135-2162, September 2026.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Variation in the Circulating Levels of Retinoic Acid and Type 2 Diabetes: Relationships with Glycemic Control Indices, Disease Treatment and Complications. [PDF]

Diagnostics (Basel)
Alsaidan AA, Alomair BM, Almaeen AH, Aldirbas JMQ, Alanazi BRS, Algaed RHS, Alruwaili AFB, Alruwaili NMS, Aljbab DFA, Alenzi LAA, Albalawi RSS, Mohamed AA, El-Metwally TH.   +12 more
europepmc   +1 more source