Results 251 to 260 of about 821,561 (307)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]

FASEB J
Wang H, Liu X, Gravesteijn G, Atella A, Liu J, Rutten JW, Ten Dijke P, Gonçalves MAFV, Lesnik Oberstein SAJ, Baker DA.   +9 more
europepmc   +1 more source

Estudo Abrangente do Resveratrol Associado à Sulfadiazina em Linfócitos Infectados com Toxoplasma gondii: Envolvimento da Sinalização Purinérgica na Resposta Imunológica. [PDF]

Acta Parasitol
Bottari NB, Copetti PM, Bissacotti BF, Vidal T, Da Silva AD, Fracasso M, Reichert KP, Nauderer J, Morsch VMM, Melazzo C, Da Silva AS, Schetinger MRC.   +11 more
europepmc   +1 more source

Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug-Based In Situ Tissue Engineering. [PDF]

Stem Cells Int
Sonnleitner J, Gulich K, Pruss A, Perka C, Gursche A, Kendoff D, Sittinger M, Hemmati-Sadeghi S, Dehne T.   +8 more
europepmc   +1 more source

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies. [PDF]

Cancer Rep (Hoboken)
Mathibela SP, Lebelo MT, Steenkamp V.
europepmc   +1 more source

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Sigma Receptors – Literature Review

Journal of Diseases Disorders & Treatments, 2022
The paper reviewed data confirming that sigma1 receptors modulate NMDA neurotransmission. It has been established that they can enhance the spontaneous release of glutamate in the hippocampus, potentiate the release of a neurotrophic factor induced by glutamate, and also participate in the processes of synaptic restructuring (facilitation of long-term ...
Lizaveta IB, Lychkovskaya MA, Kudyan IA, Kudyan MG   +3 more
openaire   +1 more source

Sigma Receptors and Cocaine Abuse

Current Topics in Medicinal Chemistry, 2011
Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine. Strategies to reduce the access of cocaine to sigma receptors have included antisense oligonucleotides to the sigma-1 receptor protein as well as small molecule ligand with affinity for sigma ...
Sanju, Narayanan, Christophe, Mesangeau, Jacques H, Poupaert, Christopher R, McCurdy   +3 more
openaire   +2 more sources

Sigma Receptors and Cancer

Cancer Research, 2004
Abstract The sigma (σ) receptor and its agonists have been implicated in a myriad of cellular functions, biological processes and diseases. Whereas the precise molecular mechanism(s) of σ receptors and their involvement in cancer cell biology have not been elucidated, recent work has started to shed some light on these issues.
Ebru Aydar, Christopher P. Palmer, Mustafa B. A. Djamgoz   +2 more
openaire   +1 more source

Sigma-1 Receptor and Pain

2017
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos, Luz, Romero, Daniel, Zamanillo, Carlos, Plata-Salamán, José Miguel, Vela   +4 more
openaire   +2 more sources

Sigma-2 Receptor Ligands: Neurobiological Effects

Current Medicinal Chemistry, 2015
Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its molecular size is about 18 kDa. Recent studies indicated that sigma-2 receptor modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced
Lin, Guo, Xuechu, Zhen
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