Results 261 to 270 of about 821,561 (307)

(Aminoalkoxy)chromones. Selective .sigma. receptor ligands

Journal of Medicinal Chemistry, 1992
A series of (aminoalkoxy)chromones has been prepared, members of which bind potently (16-100 nM) at the sigma binding site and bind weakly (greater than 1000 nM) at the dopamine D2 receptor and 33 other receptors, second messenger systems, and ion channels.
R H, Erickson, K J, Natalie, W, Bock, Z, Lu, F, Farzin, R G, Sherrill, D J, Meloni, R J, Patch, W J, Rzesotarski, J, Clifton   +9 more
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Sigma receptors in schizophrenic cerebral cortices

Neurochemical Research, 1992
Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1,
H, Shibuya, H, Mori, M, Toru
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[Sigma (sigma) receptor and neurosteroids].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000
Studies on the sigma receptor and related compounds are becoming more attractive since they were found to be closely related to higher brain functions such as memory, learning, depression, anxiety, schizophrenia and neuroprotection. Along with these pharmacological findings, the single transmembrane-type, non-metabotropic sigma binding protein has been
H, Ueda, A, Yoshida
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Sigma receptors: biology and therapeutic potential

Psychopharmacology, 2004
More than 20 years after the identification of the sigma receptors as a unique binding site in the brain and in the peripheral organs, several questions regarding this receptor are still open. Only one of the subtypes of the receptor has been cloned to date, but the endogenous ligand still remains unknown, and the possible association of the receptor ...
Xavier, Guitart, Xavier, Codony, Xavier, Monroy   +2 more
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Sigma opioid receptor; SKF-10,047 update

Neuropeptides, 1985
We found that (-)-SKF-10,047 blocks EEG and behavioral effects of morphine in the naive rat, precipitates withdrawal in morphine-dependent rats, produces physical dependence as evidenced by naloxone-induced withdrawal, and displaces [3H] dihydromorphine from brain homogenates. (+)-SKF-10,047 did not produce dependence upon chronic treatment, and it did
N, Khazan, G A, Young, E E, el-Fakahany, O, Hong, D, Calligaro   +4 more
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Sigma-1 receptor and inflammatory pain

Inflammation Research, 2015
The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G protein-coupled receptors and ion channels to modulate their activity. Sig-1R is located in areas of the central and peripheral nervous system that are key to pain control.
Georgia, Gris, Enrique José, Cobos, Daniel, Zamanillo, Enrique, Portillo-Salido   +3 more
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Sigma Receptors and Alcohol Use Disorders

2016
Although extensive research has focused on understanding the neurobiological mechanisms underlying alcohol addiction, pharmacological treatments for alcohol use disorders are very limited and not always effective. This constraint has encouraged the search for novel pharmacological targets for alcoholism therapy.
Valentina, Sabino, Pietro, Cottone
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Sigma receptor modulators: a patent review

Expert Opinion on Therapeutic Patents, 2013
Sigma receptors are involved in several central nervous system (CNS) disorders, including mood disorders (depression and anxiety), psychosis, schizophrenia, movement disorders (i.e., Parkinson's disease) and memory deficits (i.e., Alzheimer's disease).
COLLINA, SIMONA, GAGGERI, RAFFAELLA FRANCESCA, MARRA, ANNAMARIA, NEGRINOTTI, SARA, NEGRI, FRANCESCA, ROSSI, DANIELA, Bassi A   +6 more
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Sigma Receptors and Substance Use Disorders

2017
Thanks to advances in neuroscience, addiction is now recognized as a chronic brain disease with genetic, developmental, and cultural components. Drugs of abuse, including alcohol, are able to produce significant neuroplastic changes responsible for the profound disturbances shown by drug addicted individuals.
Valentina, Sabino, Callum, Hicks, Pietro, Cottone   +2 more
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Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples

Bioorganic & Medicinal Chemistry Letters, 2016
Analogues of the decahydrobenzoquinolin-5-one class of sigma (σ) receptor ligands were used to probe the structure-activity relationship trends for this recently discovered series of σ ligands. In all, 29 representatives were tested for σ and opioid receptor affinity, leading to the identification of compounds possessing improved σ1 selectivity and ...
Michael C, McLeod, Jeffrey, Aubé, Kevin J, Frankowski   +2 more
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