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Sigma-1 Receptor in Motoneuron Disease
2017Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal ...
Mancuso, Renzo, Navarro, Xavier
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Sigma-1 Receptor and Neuronal Excitability
2017The sigma-1 receptor (Sig-1R), via interaction with various proteins, including voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the ...
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The evolving theory of quality management: The role of Six Sigma
Journal of Operations Management, 2008Lawrence Fredendall
exaly
Neuroleptic drugs and the sigma receptor
American Journal of Psychiatry, 1990openaire +2 more sources
Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution
Biomolecules, 2015Mark Paget
exaly
Benefits, obstacles, and future of six sigma approach
Technovation, 2006Young Hoon Kwak, Frank T Anbari
exaly