Results 151 to 160 of about 587,245 (265)

Small Bowel Cancer: Implications of Preoperative Work‐Up on Surgical Strategy

World Journal of Surgery, Volume 50, Issue 10, Page 3008-3019, October 2026.
Small bowel cancers comprise a heterogeneous group of malignancies, making diagnosis and treatment challenging. This study aimed to evaluate the ability of preoperative diagnostic work‐up to predict clinical and histopathological findings, facilitate subgroup identification, and support tailored, individualized surgical strategies. Preoperative work‐up
Erik Kjæstad, Espen Thiis‐Evensen, Anita Sveen, Arne Olav Bakka, Johannes Kurt Schultz   +4 more
wiley   +1 more source

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

World Journal of Surgery, Volume 50, Issue 10, Page 2996-3007, October 2026.
There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challenging, especially when small intestinal neuroendocrine tumor (siNET) metastases give rise to ...
Erik Kjæstad, Espen Thiis‐Evensen, Bjørn Edwin, Arne Olav Bakka, Anne Helene Lilleaas, Yngve Thorsen, Johannes Kurt Schultz   +6 more
wiley   +1 more source

Growth hormone-releasing hormone, growth hormone, and neuroendocrine tumors. [PDF]

J Clin Transl Endocrinol
Shahid M, Koch CA.
europepmc   +1 more source

Human β‐Cell Dedifferentiation and Diabetes

Journal of Diabetes, Volume 18, Issue 10, October 2026.
Human β‐cell dedifferentiation is inversely associated with HOMA‐β and occurs in Type 2 diabetes, Type 3c diabetes, and age‐related diabetes, potentially before hyperglycemia develops. Progressive loss of β‐cell identity is accompanied by dedifferentiation and transdifferentiation, suggesting that reversing these cell‐state changes may help restore ...
Jiajun Sun, Jinsook Son, Qidi Wang
wiley   +1 more source

Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia. [PDF]

Ann N Y Acad Sci
Fatehi S, Rocheleau JV, Riddell MC.
europepmc   +1 more source

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

Aging Cell, Volume 25, Issue 10, October 2026.
Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Eva Tudurí, Lucía Almagro, Ana Ojeda‐Rodríguez, Raquel Pascua‐Maestro, Henver S. Brunetta, Sergi Soriano, Alejandro López‐Moreno, Talía Boronat‐Belda, Sergio Velasco‐Avilés, Joel Alves da Silva Junior, Manuel Castellano‐Muñoz, Alex Rafacho, Irene Cózar‐Castellano, Ángel Nadal, Paloma Alonso‐Magdalena, Beatriz Merino, José López‐Miranda, Ivan Quesada   +17 more
wiley   +1 more source

Oligomerization of somatostatin receptors

, 2002
Oligomerization of membrane proteins in response to external stimulation is a common event in cell signalling for generating functional diversity. In the case of the heptahelical receptor (HHR) superfamily, the traditional view has been that these ...
Rocheville, Magalie
core  

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Octreotide-Mediated Co-Solubilization of Paclitaxel and Docetaxel: A Novel Targeted Formulation for Synergistic Anticancer Chemotherapy. [PDF]

Pharmaceutics
Abdellatif AAH, Tawfeek HM, El-Readi MZ, Alharbi AE, Maswadeh HM, Amin MA, Eid SY, Ellethy AT, Refaat B, Aslam A, Altowayan WM, Younis MA.   +11 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source