Results 21 to 30 of about 5,502 (182)
Frontiers in Neuroscience, 2014 The roles of 5-HT3 and 5-HT4 receptors in the modulation of intestinal propulsion by luminal application of 5-HT and augmentation of endogenous 5-HT effects were studied in segments of guinea-pig ileum in vitro. Persistent propulsive contractions evoked
Rachel M Gwynne +3 more
doaj +1 more source
iScience, 2023 Summary: Neurons contribute to the regeneration of projected tissues; however, it remains unclear whether they are involved in the non-innervated tissue regeneration.
Soshiro Kashio +2 more
doaj +1 more source
Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors. [PDF]
PLoS ONE, 2016 Millions of patients suffer from lymphedema worldwide. Supporting the contractility of lymphatic collectors is an attractive target for pharmacological therapy of lymphedema. However, lymphatics have mostly been studied in animals, while the cellular and
Viktoria Hasselhof +7 more
doaj +1 more source
Bidirectional Regulation of Human Colonic Smooth Muscle Contractility by Tachykinin NK2 Receptors
Journal of Pharmacological Sciences, 2011 .: In this study, we attempted to clarify the mechanism of tachykinin-induced motor response in isolated smooth muscle preparations of the human colon. Fresh specimens of normal colon were obtained from patients suffering from colonic cancer.
Akihiro Nakamura +6 more
doaj +1 more source
Neurokinin receptors in the gastrointestinal muscle wall: cell distribution and possible roles
Biomolecular Concepts, 2013 The neurokinin receptors are G-protein-linked receptors; three distinct molecules, called neurokinin-1, neurokinin-2, and neurokinin-3 receptors, have been identified.
Vannucchi Maria Giuliana +1 more
doaj +1 more source
Journal of Pharmacological Sciences, 2008 The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells ...
Yumi Watanabe +7 more
doaj +1 more source
Medullary tachykinin precursor 1 neurons promote rhythmic breathing
eLife, 2023 Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau +4 more
doaj +1 more source
Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle
Journal of Pharmacological Sciences, 2007 We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 – 10 mM had no effect on the tone of those preparations without precontraction.
Satoko Kubo +3 more
doaj +1 more source
Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel +5 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in animals and humans, which transmit various signals from the extracellular environment into cells.
Yan-Li Li +7 more
doaj +1 more source