Results 31 to 40 of about 579,792 (173)

Pharmacological Characterization of T-2328, 2-Fluoro-4’-methoxy- 3’-[[[(2S,3S )-2-phenyl-3-piperidinyl]amino]methyl]-[1,1’-biphenyl]-4- carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK1Receptor

Journal of Pharmacological Sciences, 2008
The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells ...
Yumi Watanabe, Hidetoshi Asai, Taketoshi Ishii, Satoko Kiuchi, Masahito Okamoto, Hiroyuki Taniguchi, Masaaki Nagasaki, Akira Saito   +7 more
doaj   +1 more source

Medullary tachykinin precursor 1 neurons promote rhythmic breathing

eLife, 2023
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L Horner, Gaspard Montandon   +4 more
doaj   +1 more source

Tachykinin-related peptides and their receptors in invertebrates: a current view4387

, 2010
Members of the tachykinin peptide family have been well conserved during evolution and are mainly expressed in the central nervous system and in the intestine of both vertebrates and invertebrates. In these animals, they act as multifunctional messengers
Van Loy, Tom, Poels, Jeroen, Van Hiel, Boris, Verlinden, Heleen, Vandersmissen, Hans Peter, Vanden Broeck, Jozef, Jeroen Poels, V. Broeck, Hans Peter Vandersmissen, Jozef Vanden Broeck, H.P. Vandersmissen, Tom Van Loy, T. Van Loy, H. Verlinden, Heleen Verlinden, Matthias B. Van Hiel, J. Poels, M.B. Van Hiel   +17 more
core   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle

Journal of Pharmacological Sciences, 2007
We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 – 10 mM had no effect on the tone of those preparations without precontraction.
Satoko Kubo, Ichiko Doe, Yuko Kurokawa, Atsufumi Kawabata   +3 more
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

The Gastric Ganglion of Octopus vulgaris: Preliminary Characterization of Gene- and Putative Neurochemical-Complexity, and the Effect of Aggregata octopiana Digestive Tract Infection on Gene Expression

Frontiers in Physiology, 2017
The gastric ganglion is the largest visceral ganglion in cephalopods. It is connected to the brain and is implicated in regulation of digestive tract functions.
Elena Baldascino, Giulia Di Cristina, Perla Tedesco, Carl Hobbs, Tanya J. Shaw, Giovanna Ponte, Giovanna Ponte, Paul L. R. Andrews, Paul L. R. Andrews   +8 more
doaj   +1 more source

Transcriptome of the female synganglion of the black-legged tick Ixodes scapularis (Acari: Ixodidae) with comparison between Illumina and 454 systems. [PDF]

PLoS ONE, 2014
Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods.
Noble Egekwu, Daniel E Sonenshine, Brooke W Bissinger, R Michael Roe   +3 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Gene expression of muscarinic, tachykinin and purinergic receptors in porcine bladder: comparison with cultured cells

Frontiers in Pharmacology, 2013
Urothelial cells, myofibroblasts, and smooth muscle cells are important cell types contributing to bladder function. Multiple receptors including muscarinic (M3/M5), tachykinin (NK1/NK2) and purinergic (P2X1/P2Y6) receptors are involved in bladder motor ...
Forough eBahadory, Kate Hilda Moore, Lu eLiu, Elizabeth eBurcher   +3 more
doaj   +1 more source