Results 51 to 60 of about 5,502 (182)

More than two decades of research on insect neuropeptide GPCRs: an overview

Frontiers in Endocrinology, 2012
This review focuses on the state of the art on neuropeptide receptors in insects. Most of these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation of virtually all physiological processes during an insect’s life.
Jelle eCaers, Heleen eVerlinden, Sven eZels, Hans Peter eVandersmissen, Kristel eVuerinckx, Liliane eSchoofs   +5 more
doaj   +1 more source

Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases

The Journal of Dermatology, Volume 53, Issue 7, Page 967-979, July 2026.
ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley   +1 more source

Tachykinin-Related Peptides Share a G Protein-Coupled Receptor with Ion Transport Peptide-Like in the Silkworm Bombyx mori. [PDF]

PLoS ONE, 2016
Recently, we identified an orphan Bombyx mori neuropeptide G protein-coupled receptor (BNGR)-A24 as an ion transport peptide-like (ITPL) receptor. BNGR-A24 belongs to the same clade as BNGR-A32 and -A33, which were recently identified as natalisin ...
Chiaki Nagai-Okatani, Hiromichi Nagasawa, Shinji Nagata   +2 more
doaj   +1 more source

Laparoscopic resection of small bowel neuroendocrine tumors: A long‐term survival analysis

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Small bowel neuroendocrine tumors (SBNET) are rare neoplasms that often present insidiously and may be associated with mesenteric fibrosis and advanced disease at diagnosis. While open surgery has traditionally been the standard of care, the role of laparoscopic resection in patients with complex SBNET remains under evaluation.
Michal Perets, Ofra Carmel, Anoushka Adler, Nir Horesh, Simona Grozinsky‐Glasberg, Petachia Reissman, Michael R. Freund   +6 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

CONFORMATIONAL STUDIES OF TACHYKININ PEPTIDES USING NMR SPECTROSCOPY

TASK Quarterly, 1998
Conformational analysis of two tachykinin family peptides: Scyliorhinin I (Seyl) and Scyliorhinin II (Scyll) was carried out by 1D- and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, NOESY and ROESY) and molecular dynamics calculation methods in water and DMSO ...
SYLWIA RODZIEWICZ, XIAO-FEI QI, KRZYSZTOF ROLKA   +2 more
doaj  

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Task Performance and Queen Presence Influence the Brain Transcriptome in a Bumble Bee (Bombus terrestris) With a Flexible Division of Labour System

Molecular Ecology, Volume 35, Issue 11, June 2026.
ABSTRACT Division of labour in reproduction and in task performance are two hallmarks of insect societies. Bumble bees and honey bees are both classified as eusocial, but differ in the social organization of their colonies and in the hormonal regulation of division of labour.
Hagai Yehoshua Shpigler, Brian Herb, Molly Avidan‐King, Sivan Alkalay Oren, Mira Cohen, Jenny Drnevich, Mark Band, Gene E. Robinson, Guy Bloch   +8 more
wiley   +1 more source

Intrathecally Administered D-Cycloserine Produces Nociceptive Behavior Through the Activation of N-Methyl-D-aspartate Receptor Ion-Channel Complex Acting on the Glycine Recognition Site

Journal of Pharmacological Sciences, 2007
Intrathecal (i.t.) administration of D-cycloserine (100 and 300 fmol), a partial agonist of the glycine recognition site on the N-methyl-D-aspartate (NMDA) receptor ion-channel complex, produced a behavioral response mainly consisting of biting and/or ...
Koichi Tan-No, Akihisa Esashi, Osamu Nakagawasai, Fukie Niijima, Seiichi Furuta, Takumi Sato, Susumu Satoh, Hajime Yasuhara, Takeshi Tadano   +8 more
doaj   +1 more source