Results 51 to 60 of about 579,792 (173)

Tachykinin NK1 receptors are involved in proteinase-activated receptor-2-mediated visceral hyperalgesia in rats

, 2001
Tachykinin NK1 receptors are involved in proteinase-activated receptor-2-mediated visceral hyperalgesia in rats. 18.
Fioramonti, Jean, Guiard, Bruno, Cenac, Nicolas, Garcia Villar, Rafael, Coelho, Anne-Marie, Bueno, Lionel   +5 more
core   +2 more sources

Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation

Frontiers in Molecular Neuroscience, 2023
The tachykinin hemokinin-1 (HK-1) is involved in immunological processes, inflammation, and pain. Although the neurokinin 1 receptor (NK1R) is described as its main target, several effects are mediated by currently unidentified receptor(s).
Krisztina Takács-Lovász, Timea Aczél, Éva Borbély, Éva Borbély, Éva Szőke, Éva Szőke, Éva Szőke, Lilla Czuni, Péter Urbán, Attila Gyenesei, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, József Kun, József Kun, Kata Bölcskei   +16 more
doaj   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

BMC Bioinformatics, 2010
Background G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to understand the characteristics of individual GPCRs and their subtypes ...
Emmerich Michael TM, van Vlijmen Herman WT, Lane Jonathan R, Beukers Margot W, IJzerman Adriaan P, Peironcely Julio E, van der Horst Eelke, Okuno Yasushi, Bender Andreas   +8 more
doaj   +1 more source

A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila

Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.
Neurosecretory cells of the brain are mostly the same in larvae and adults of Drosophila melanogaster and they produce the same neuropeptides and peptide hormones (NPHs), yet their functional roles differ to a large extent between the two stages. Many other peptidergic neurons change both in numbers and function.
Dick R. Nässel
wiley   +1 more source

Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Tachykinin receptors (provisional nomenclature as recommended by NC-IUPHAR [90]) are activated by the endogenous peptides substance P (SP), neurokinin A (NKA; previously known as substance K, neurokinin α, neuromedin L), neurokinin B (NKB ...
Heyward, Christa Y., Leeman, Susan E., Dombrowsky, Erin, Fong, Tung M., Barrett, Jeffrey, Coulson, Joseph, Remeshwar, Pranela, Canning, Brenden, Douglas, Steven D.   +8 more
core   +1 more source

Proteomic profiling identifies candidate biomarkers for small intestinal neuroendocrine tumours G1 and G2

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Although small intestinal neuroendocrine tumours (SI‐NET) Grade 1 (G1) and 2 (G2) are often studied together, clinical course and response to treatment may differ. We hypothesized that these tumour groups express different markers in blood that may inform future treatment strategies. Blood from 107 SI‐NET patients (G1 n = 64, G2 n = 43) and 50
Malin Grönberg, Dimitrios Papantoniou, Eva Tiensuu Janson   +2 more
wiley   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Increased sensitivity to visceral distension in post-Nippostrongylus brasiliensis-infected rats: involvement of mast cells and tachykinin receptors

, 1997
Increased sensitivity to visceral distension in post-Nippostrongylus brasiliensis-infected rats: involvement of mast cells and tachykinin receptors.
McLean, P G, Ducos de Lahitte, Jacques, Fioramonti, Jean, Moré, Jean, Garcia Villar, Rafael, Picard, Céline, Bueno, Lionel   +6 more
core   +3 more sources

Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome

Scientific Reports, 2018
Neuropeptides are diverse and evolutionarily ancient regulators of physiological/behavioural processes in animals. Here we have investigated the evolution and comparative physiology of luqin-type neuropeptide signalling, which has been characterised ...
Luis Alfonso Yañez-Guerra, Jérôme Delroisse, Antón Barreiro-Iglesias, Susan E. Slade, James H. Scrivens, Maurice R. Elphick   +5 more
doaj   +1 more source