Results 71 to 80 of about 579,792 (173)
Journal of Pharmacological Sciences, 2007 Intrathecal (i.t.) administration of D-cycloserine (100 and 300 fmol), a partial agonist of the glycine recognition site on the N-methyl-D-aspartate (NMDA) receptor ion-channel complex, produced a behavioral response mainly consisting of biting and/or ...
Koichi Tan-No +8 more
doaj +1 more source
Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders
Experimental Dermatology, Volume 35, Issue 8, August 2026.ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley +1 more source
Physiological mechanisms and therapeutic targets in chronic cough
Physiological Reports, Volume 14, Issue 15, August 2026.Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown +3 more
wiley +1 more source
Location and activation of tachykinin NK3 receptors in the small intestine of guinea pig and rat
, 2000 Location and activation of tachykinin NK3 receptors in the small intestine of guinea pig and ...
John Furness (13070439) +3 more
core
Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK1 and NK2 tachykinin receptors [PDF]
, 2020 There is increasing focus on the involvement of tachykinins in immune and inflammatory responses. Hemokinin-1 (HK-1) is a recently identified tachykinin that originates primarily from immune cells, and has structural similarities to substance P (SP ...
Burcher, E +3 more
core +1 more source
Supraspinal Circuit Mechanisms Underlying Itch Processing
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Yuncheng Luo +3 more
wiley +1 more source
, 2000 Independent endocytosis of the NK1 and NK3 tachykinin receptors in neurons of the rat myenteric ...
BR Southwell (14473155) +3 more
core
Long-Lasting Anti-emetic Effect of T-2328, a Novel NK1 Antagonist
Journal of Pharmacological Sciences, 2008 The effect of T-2328 {2-fluoro-4’-methoxy-3’-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino]methyl]-[1,1’-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK1–receptor antagonist, was examined on cisplatin-induced emesis in ferrets.
Yumi Watanabe +6 more
doaj +1 more source
European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian +8 more
wiley +1 more source
Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice
Frontiers in Cellular Neuroscience, 2017 The antero-ventral periventricular zone (AVPV) and medial preoptic area (MPOA) have been recognized as gonadal hormone receptive regions of the rodent brain that—via wiring to gonadotropin-releasing hormone (GnRH) neurons—contribute to orchestration of ...
Csaba Vastagh +2 more
doaj +1 more source