Results 61 to 70 of about 579,792 (173)

Types of Neurons in the Myenteric Plexus of Human Gastric Corpus Identified by Multi‐Layer Immunohistochemical Coding and Vagal Tracing

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
Myenteric nerve cell bodies in the human gastric corpus were divided into 12 classes by the combinatorial expression of 15 neuronal markers, using multiplexed immunohistochemistry (1084 neurons from 7 individuals). Baskets of axonal varicosities from vagal or enteric sources were analyzed to detect targeted patterns of connectivity ...
M. E. Johnson, M. Wee, B. N. Chen, A. Humenick, R. A. Peterson, W. P. Yew, T. J. Hibberd, D. A. Wattchow, L. Kow, T. L. Powley, S. J. H. Brookes   +10 more
wiley   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice

, 2001
Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice.
Fioramonti, Jean, Cenac, Nicolas, Guiard, Bruno, Garcia Villar, Rafael, Bueno, Lionel   +4 more
core   +2 more sources

Age‐Related Decreases in Colonic Neurokinin A Content and Release Monitored Using Electrochemical Immunosensors

Neurogastroenterology &Motility, Volume 38, Issue 9, September 2026.
A 3D‐printed electrochemical immunosensor revealed significant age‐related reductions in colonic Neurokinin A (NKA) content and release. Decreased fecal NKA levels mirrored tissue changes, highlighting the potential of NKA as a noninvasive biomarker of age‐related bowel dysfunction.
Chloe Miller, Mark Yeoman, Bhavik Anil Patel   +2 more
wiley   +1 more source

More than two decades of research on insect neuropeptide GPCRs: an overview

Frontiers in Endocrinology, 2012
This review focuses on the state of the art on neuropeptide receptors in insects. Most of these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation of virtually all physiological processes during an insect’s life.
Jelle eCaers, Heleen eVerlinden, Sven eZels, Hans Peter eVandersmissen, Kristel eVuerinckx, Liliane eSchoofs   +5 more
doaj   +1 more source

Evolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling

Frontiers in Neuroscience, 2020
Luqin is a neuropeptide that was discovered and named on account of its expression in left upper quadrant cells of the abdominal ganglion in the mollusc Aplysia californica.
Luis Alfonso Yañez-Guerra, Maurice R. Elphick   +1 more
doaj   +1 more source

CONFORMATIONAL STUDIES OF TACHYKININ PEPTIDES USING NMR SPECTROSCOPY

TASK Quarterly, 1998
Conformational analysis of two tachykinin family peptides: Scyliorhinin I (Seyl) and Scyliorhinin II (Scyll) was carried out by 1D- and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, NOESY and ROESY) and molecular dynamics calculation methods in water and DMSO ...
SYLWIA RODZIEWICZ, XIAO-FEI QI, KRZYSZTOF ROLKA   +2 more
doaj  

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

Tachykinin-Related Peptides Share a G Protein-Coupled Receptor with Ion Transport Peptide-Like in the Silkworm Bombyx mori. [PDF]

PLoS ONE, 2016
Recently, we identified an orphan Bombyx mori neuropeptide G protein-coupled receptor (BNGR)-A24 as an ion transport peptide-like (ITPL) receptor. BNGR-A24 belongs to the same clade as BNGR-A32 and -A33, which were recently identified as natalisin ...
Chiaki Nagai-Okatani, Hiromichi Nagasawa, Shinji Nagata   +2 more
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source