Results 61 to 70 of about 5,502 (182)
Advanced Science, Volume 13, Issue 29, 22 May 2026.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, Volume 13, Issue 29, 22 May 2026.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Long-Lasting Anti-emetic Effect of T-2328, a Novel NK1 Antagonist
Journal of Pharmacological Sciences, 2008 The effect of T-2328 {2-fluoro-4’-methoxy-3’-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino]methyl]-[1,1’-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK1–receptor antagonist, was examined on cisplatin-induced emesis in ferrets.
Yumi Watanabe +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice
Frontiers in Cellular Neuroscience, 2017 The antero-ventral periventricular zone (AVPV) and medial preoptic area (MPOA) have been recognized as gonadal hormone receptive regions of the rodent brain that—via wiring to gonadotropin-releasing hormone (GnRH) neurons—contribute to orchestration of ...
Csaba Vastagh +2 more
doaj +1 more source
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?
Toxins, 2015 Therapeutic outcome in head and neck squamous cell carcinoma (HNSCC) is poor in most advanced cases. To improve therapeutic efficiency, novel therapeutic targets and prognostic factors must be discovered.
Takeharu Kanazawa +7 more
doaj +1 more source
iScienceSummary: Chemical synaptic transmission is modulated to accommodate different activity levels, thus enabling homeostatic scaling in pre- and postsynaptic compartments.
Holger Dill +4 more
doaj +1 more source
Neurobiology of Disease, 2011 Substance P (SP), a neuropeptide member of the tachykinin (TK) family, has a functional role both in physiological and pathological conditions, including Amyotrophic Lateral Sclerosis disease.
Silvia Caioli +6 more
doaj +1 more source
iScienceSummary: Tachykinins are short neuropeptides, such as substance P and neurokinin B, that have been shown to interact with Alzheimer’s β-amyloid (Aβ) peptide.
Mohsen Habibnia +4 more
doaj +1 more source
Food Science and Human WellnessMoringa oleifera have laxative effects, but their active compositions and mechanisms are not very clear thus far. To this end, we systematically explored the active components and mechanism of M.
Sijin Li +8 more
doaj +1 more source