Results 1 to 10 of about 78,914 (316)

Effects of Heparin and Bivalirudin on Thrombin-Induced Platelet Activation: Differential Modulation of PAR Signaling Drives Divergent Prothrombotic Responses

Frontiers in Cardiovascular Medicine, 2021
Heparin and bivalirudin are widely used as anticoagulants in the setting of acute thrombosis. In this study, we investigated how these drugs affect the ability of thrombin to generate a prothrombotic platelet response via activation of the protease ...
Mikael Lund, Ankit S. Macwan, Kjersti Tunströmer, Tomas L. Lindahl, Tomas L. Lindahl, Niklas Boknäs, Niklas Boknäs   +6 more
doaj   +1 more source

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay

Frontiers in Pharmacology, 2020
The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders.
Isra Al Zamel, Abdulrasheed Palakkott, Arshida Ashraf, Rabah Iratni, Mohammed Akli Ayoub   +4 more
doaj   +1 more source

Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury

Journal of Neuroinflammation, 2022
Background The danger-associated molecular patterns (DAMPs) are critical contributors to the progressive neuropathology and thereafter affect the functional outcomes following spinal cord injury (SCI).
Ting Yang, Haiyan Jiang, Xinye Luo, Yuxuan Hou, Aicheng Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Honghua Song, Rixin Cai, Xudong Wang, Yingjie Wang, Chun Yao, Lei Qi, Yongjun Wang   +14 more
doaj   +1 more source

Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

Journal of Pharmacological Sciences, 2022
Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs)
Akihiro Okamura, Junichiro Miake, Takuya Tomomori, Aiko Takami, Tatsuya Sawano, Masaru Kato, Kazuyoshi Ogura, Daiki Tsujimoto, Shunsuke Kawatani, Kurniawan Priyono Agung, Tomomi Notsu, Ichiro Hisatome, Kazuhiro Yamamoto, Takeshi Imamura   +13 more
doaj   +1 more source

Dynamic allostery in thrombin—a review

Frontiers in Molecular Biosciences, 2023
Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C ...
Elizabeth A. Komives
doaj   +1 more source

Thrombin-Receptor Activation and Thrombin-Induced Brain Tolerance [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2002
The authors previously found that pretreatment with a low dose of thrombin attenuates the brain edema induced by a large dose of thrombin or an intracerebral hemorrhage, and reduces infarct volume after focal cerebral ischemia (i.e., thrombin preconditioning).
Yajun, Jiang, Jimin, Wu, Ya, Hua, Richard F, Keep, Jianming, Xiang, Julian T, Hoff, Guohua, Xi   +6 more
openaire   +2 more sources

Activation‐induced changes in platelet surface receptor expression and the contribution of the large‐platelet subpopulation to activation

Research and Practice in Thrombosis and Haemostasis, 2020
Objective Platelet surface receptors are also present subcellularly in organelle membranes and can be expressed on the surface upon platelet activation. However, some receptors were reported to be decreased after activation.
Masaaki Moroi, Richard W. Farndale, Stephanie M. Jung   +2 more
doaj   +1 more source

Constitutive Expression of Functionally Active Protease-Activated Receptors 1 and 2 in Human Conjunctival Epithelial Cells

Mediators of Inflammation, 2006
Protease-activated receptors (PARs) are G-protein-coupled receptors which initiate inflammatory responses when activated by specific serine proteases.
Timothy J. Nickel, Mohammad H. Kabir, Jaya Talreja, Daniel J. Stechschulte, Kottarappat N. Dileepan   +4 more
doaj   +2 more sources

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants

Platelets, 2021
Factor Xa (FXa) and thrombin exert non-hemostatic cellular actions primarily mediated through protease-activated receptors (PARs). We investigated the effect of FXa and thrombin on human late-outgrowth endothelial cells (OECs), a type of endothelial ...
Styliani Papadaki, Sofia Sidiropoulou, Iraklis C. Moschonas, Alexandros D. Tselepis   +3 more
doaj   +1 more source

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]

, 2003
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio, Marinissen, Maria Julia, Offermanns, Stefan, Servitja, Joan-Marc, Simon, Melvin I.   +4 more
core   +1 more source