Coagulation, Microenvironment and Liver Fibrosis
Cells, 2018 Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead ...
Niccolò Bitto +2 more
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Scientific Reports, 2022 Patients with obstructive sleep apnea/hypopnea (OSA) are at high risk of cerebrovascular diseases leading to cognitive impairment. The oxidative stress generated by intermittent hypoxia (IH) could lead to an increase in blood–brain barrier (BBB ...
Cindy Zolotoff +3 more
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Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]
, 2017 The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C +3 more
core +1 more source
Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]
, 2006 Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core +2 more sources
Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.
PLoS ONE, 2020 Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura +5 more
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Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor
Cell Death Discovery, 2022 Spinal cord injury (SCI) will result in the significant elevation of thrombin production at lesion site via either breakage of blood-spinal cord barrier or upregulated expression within nerve cells.
Xiaojun Chen +10 more
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A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin. [PDF]
PLoS ONE, 2011 BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport.
Rehana Perveen +7 more
doaj +1 more source
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]
, 2009 Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian +79 more
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Antiplatelet therapy: thrombin receptor antagonists [PDF]
British Journal of Clinical Pharmacology, 2011 Activated platelets stimulate thrombus formation in response to rupture of an atherosclerotic plaque or endothelial cell erosion, promoting atherothrombotic disease. Multiple pathways contribute to platelet activation. Aspirin, an irreversible inhibitor of thromboxane A2 synthesis, in combination with clopidogrel, an inhibitor of P2Y12 adenosine ...
Antonio, Tello-Montoliu +3 more
openaire +2 more sources
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts [PDF]
, 2005 Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells.
Kurose, Hitoshi +4 more
core +2 more sources