Results 161 to 170 of about 13,430 (194)
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Ontogeny of receptors for thyrotropin-releasing hormone in the rat brain
Developmental Brain Research, 1986Developmental changes in the thyrotropin-releasing hormone (TRH) receptor concentrations of hypothalamic and certain extrahypothalamic structures in the rat were evaluated from 2 days after birth until sexual maturity. The maturational pattern of TRH receptors in hypothalamus, striatum and amygdala follow that of the pituitary and all show the same ...
L, Blanchard, N, Barden
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Thyrotropin releasing hormone (TRH): Apparent receptor binding in rat brain membranes
Brain Research, 1975Thyrotropin releasing hormone (TRH) binds to membranes of rat brain tissue via high- and low-affinity binding components. The high-affinity binding of TRH to brain membranes resembles binding to pituitary membranes in terms of its affinity and specificity for most peptides. In equilibrium studies, the affinity and specificity for most peptides.
D R, Burt, S H, Snyder
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Thyrotropin-releasing hormone: structure, synthesis, receptors, and basic effects
Neurochemical Journal, 2013In this review, we summarize the data on the structure, synthesis and receptors of thyrotropinreleasing hormone and its basic physiological effects. In addition to the main effect of this peptide, namely, its regulation of thyrotropin release and influence on several of the functions of the central-nervous system, the peptide influences many ...
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Thyrotropin-releasing hormone and its receptors — A hypothesis for binding and receptor activation
Pharmacology & Therapeutics, 2007Thyrotropin-releasing hormone (TRH), a tripeptide, exerts its biological effects through stimulation of cell-surface receptors, TRH-R, belonging to the superfamily of G protein-coupled receptors (GPCR). Because of the intermediate size of TRH, it is smaller than polypeptide ligands that interact at GPCR ectodomains and larger than biogenic amines ...
Stanislav, Engel, Marvin C, Gershengorn
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Biochemical and Biophysical Research Communications, 1993
We cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene and its pituitary cDNA, and examined whether TRH-R mRNA may be expressed and function in the GH-secreting pituitary adenomas of patients with acromegaly. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron
M, Yamada +7 more
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We cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene and its pituitary cDNA, and examined whether TRH-R mRNA may be expressed and function in the GH-secreting pituitary adenomas of patients with acromegaly. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron
M, Yamada +7 more
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Endocrinology, 1991
In addition to its well known actions in stimulating TSH and PRL synthesis and secretion, TRH has been shown to decrease the concentration of thyroid hormone receptors (TRs) in GH4C1 cells as measured by nuclear thyroid hormone (T3) binding. In the present study we have investigated the effects of TRH on the levels of mRNA encoding the different forms ...
K E, Jones, W W, Chin
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In addition to its well known actions in stimulating TSH and PRL synthesis and secretion, TRH has been shown to decrease the concentration of thyroid hormone receptors (TRs) in GH4C1 cells as measured by nuclear thyroid hormone (T3) binding. In the present study we have investigated the effects of TRH on the levels of mRNA encoding the different forms ...
K E, Jones, W W, Chin
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Thyrotropin-Releasing Hormone Receptor: Cloning and Regulation of Its Expression
1993Publisher Summary This chapter provides an overview of thyrotropin-releasing hormone receptor, its cloning, and the regulation of its action. The number of receptors on the surface membrane of cells may be decreased by the action of the receptor ligand or by the action of other extracellular regulatory factors that interact with other cell receptors.
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Signalling characteristics of thyrotropin releasing hormone (TRH) receptor isoforms
Biochemical Society Transactions, 1995T W, Lee, K A, Eidne, G, Milligan
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TRH-1 Thyrotropin-Releasing Hormone Receptor
2007Aylin Hanyaloglu, Karin Eidne
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