Life, 2021 Thyroid-stimulating hormone receptor (TSHR) belongs in a subfamily of the G protein-coupled receptors. Thyroid-stimulating hormone receptor gene (TSHR), a gene encoding TSHR, is a major controller of thyroid cell metabolism, and its gain of function ...
Moon Bae Ahn
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Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. [PDF]
PLoS ONE, 2010 Hormonally-regulated histone modifications that govern positive versus negative transcription of target genes are poorly characterized despite their importance for normal and pathological endocrine function.
Dongqing Wang +4 more
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PLoS ONE, 2012 Hormonal changes in humans during spaceflight have been demonstrated but the underlying mechanisms are still unknown. To clarify this point thyroid and testis/epididymis, both regulated by anterior pituitary gland, have been analyzed on long-term space ...
Maria Angela Masini +24 more
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Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis [PDF]
Endocrinology and MetabolismBackground Both Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are classified as autoimmune thyroid diseases (AITDs). It has been hypothesized that changes in the thyroid-stimulating hormone receptor (TSHR) gene may contribute to the development ...
Hendra Zufry, Timotius Ivan Hariyanto
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Microvascular Ultrasonography Vascularity Index as a Rapid and Simplified Assessment Tool for Differentiating Graves’ Disease from Destructive Thyroiditis and Managing Thyrotoxicosis [PDF]
Endocrinology and MetabolismBackground Thyrotoxicosis presents significant diagnostic challenges in distinguishing Graves’ disease (GD) from destruction-induced thyrotoxicosis (DT) using ultrasound imaging.
Han-Sang Baek +3 more
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Biochemical and physiological insights into TRH receptor-mediated signaling
Frontiers in Cell and Developmental Biology, 2022 Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the function of cells in the anterior pituitary and the central and peripheral nervous systems.
Radka Trubacova +2 more
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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Grave’s orbitopathy – an approach to clinical evaluation and management
Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012 Grave’s orbitopathy (GO), is a potentially sight threatening condition which constitutes a major clinical and therapeutic challenge and occurs in about 50% of patients with Grave’s disease with only 3-5% cases posing threat to sight.
TWN Karunasena, MWS Niranjala
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Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs
Cell Reports, 2015 Neuropeptides, representing the largest class of neuromodulators, commonly signal by G-protein-coupled receptors (GPCRs). While the neuropeptide repertoire of several metazoans has been characterized, many GPCRs are orphans.
Philipp Bauknecht, Gáspár Jékely
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The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?
Frontiers in Pharmacology, 2020 Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of ...
Jean-Louis Charli +6 more
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