Interaction of autoantibodies to thyrotropin receptor with a hydrophilic subunit of the thyrotropin receptor [PDF]
Biochemical Journal, 1985 Reduction of human thyroid membranes with dithiothreitol caused the release of a water-soluble glycoprotein which neutralized the thyrotropin (TSH) receptor-binding and thyroid-stimulating activities of Graves‘ serum. Analysis of the protein by gel filtration and sucrose density gradient centrifugation allowed estimates of 3.45 nm for the Stokes ...
E, Davies Jones +7 more
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Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. [PDF]
PLoS ONE, 2010 Hormonally-regulated histone modifications that govern positive versus negative transcription of target genes are poorly characterized despite their importance for normal and pathological endocrine function.
Dongqing Wang +4 more
doaj +1 more source
Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis [PDF]
Endocrinology and MetabolismBackground Both Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are classified as autoimmune thyroid diseases (AITDs). It has been hypothesized that changes in the thyroid-stimulating hormone receptor (TSHR) gene may contribute to the development ...
Hendra Zufry, Timotius Ivan Hariyanto
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Microvascular Ultrasonography Vascularity Index as a Rapid and Simplified Assessment Tool for Differentiating Graves’ Disease from Destructive Thyroiditis and Managing Thyrotoxicosis [PDF]
Endocrinology and MetabolismBackground Thyrotoxicosis presents significant diagnostic challenges in distinguishing Graves’ disease (GD) from destruction-induced thyrotoxicosis (DT) using ultrasound imaging.
Han-Sang Baek +3 more
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Biochemical and physiological insights into TRH receptor-mediated signaling
Frontiers in Cell and Developmental Biology, 2022 Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the function of cells in the anterior pituitary and the central and peripheral nervous systems.
Radka Trubacova +2 more
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Grave’s orbitopathy – an approach to clinical evaluation and management
Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012 Grave’s orbitopathy (GO), is a potentially sight threatening condition which constitutes a major clinical and therapeutic challenge and occurs in about 50% of patients with Grave’s disease with only 3-5% cases posing threat to sight.
TWN Karunasena, MWS Niranjala
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Thyrotropin Receptor Blocking Antibodies [PDF]
Hormone and Metabolic Research, 2018 AbstractAutoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional ...
Diana, Tanja +2 more
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Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs
Cell Reports, 2015 Neuropeptides, representing the largest class of neuromodulators, commonly signal by G-protein-coupled receptors (GPCRs). While the neuropeptide repertoire of several metazoans has been characterized, many GPCRs are orphans.
Philipp Bauknecht, Gáspár Jékely
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
TOTAL THYROIDECTOMY IN THE MANAGEMENT OF GRAVES' DISEASE [PDF]
Al-Azhar International Medical Journal, 2023 Background; Graves’ disease (GD) is an autoimmune disorder of the thyroid gland in which thyrotropin receptor antibodies (TRAb) stimulate thyroid stimulating hormone receptors (TSH-R), thereby increasing thyroid hormone production and release , Aim and ...
Mohamed Hasan +4 more
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