Results 11 to 20 of about 594,054 (285)

Functional characteristics of a variant thyrotropin receptor. [PDF]

European Journal of Biochemistry, 1996
A claim has been made that a variant of the human thyrotropin receptor in which Pro52 is replaced by Thr ([Thr52]thyrotropin receptor) is associated with autoimmune thyroid diseases and displays increased responsiveness to thyrotropin.
Cetani, Filomena, Tonacchera, Massimo, Costagliola, Sabine, Vassart, Gilbert, Van Sande, Jacqueline, Refetoff, Samuel   +5 more
core   +5 more sources

Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor. [PDF]

PLoS ONE, 2015
The thyrotropin receptor (TSHR) is a G protein-coupled receptor (GPCR) that is member of the leucine-rich repeat subfamily (LGR). In the absence of crystal structure, the success of rational design of ligands targeting the receptor internal cavity ...
Vanessa Chantreau, Bruck Taddese, Mathilde Munier, Louis Gourdin, Daniel Henrion, Patrice Rodien, Marie Chabbert   +6 more
doaj   +2 more sources

Molecular cloning of the thyrotropin receptor.

Science, 1989
The pituitary hormone thyrotropin, or thyroid-stimulating hormone (TSH), is the main physiological agent that regulates the thyroid gland. The thyrotropin receptor (TSHR) was cloned by selective amplification with the polymerase chain reaction of DNA ...
Libert, Frédérick, Parmentier, Marc, Gérard, Claude, Maenhaut, Carine, Dumont, Jacques, Perret, Jason, Lefort, Anne, Vassart, Gilbert, Van Sande, Jacqueline   +8 more
core   +4 more sources

Thyrotropin-releasing hormone receptors in GtoPdb v.2023.1 [PDF]

, 2023
Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [14]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [29].
Gershengorn, Marvin, Anthony P. Davenport, Rebecca Hills, Marvin Gershengorn, Davenport, Anthony P., Hills, Rebecca   +5 more
core   +1 more source

Autoantibody mimicry of hormone action at the thyrotropin receptor [PDF]

, 2022
Thyroid hormones are vital in metabolism, growth and development(1). Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)(2).
Dror, Ron O., Carl-Mikael Suomivuori, Szkudlinski, Mariusz W, Billesbølle, Christian B, Pinto, Antonio FM, Suomivuori, Carl-Mikael, Kaihua Zhang, Billesbølle, Christian B., Faust, Bryan, Bryan Faust, Manglik, Aashish, Christian B. Billesbølle, Zhang, Kaihua, Singh, Isha, Hoppe, Nicholas, Yifan Cheng, Muftuoglu, Yagmur, Aashish Manglik, Diedrich, Jolene K., Saghatelian, Alan, Diedrich, Jolene K, Nicholas Hoppe, Yagmur Muftuoglu, Dror, Ron O, Cheng, Yifan, Mariusz W. Szkudlinski, Antonio F. M. Pinto, Ron O. Dror, Alan Saghatelian, Szkudlinski, Mariusz W., Jolene K. Diedrich, Pinto, Antonio F. M., Isha Singh   +32 more
core   +1 more source

Interaction of autoantibodies to thyrotropin receptor with a hydrophilic subunit of the thyrotropin receptor [PDF]

Biochemical Journal, 1985
Reduction of human thyroid membranes with dithiothreitol caused the release of a water-soluble glycoprotein which neutralized the thyrotropin (TSH) receptor-binding and thyroid-stimulating activities of Graves‘ serum. Analysis of the protein by gel filtration and sucrose density gradient centrifugation allowed estimates of 3.45 nm for the Stokes ...
E, Davies Jones, F A, Hashim, Y, Kajita, F M, Creagh, P R, Buckland, V B, Petersen, R D, Howells, B, Rees Smith   +7 more
openaire   +2 more sources

Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin [PDF]

, 2013
There remains a critical need for new therapeutics that promote wound healing in patients suffering from chronic skin wounds. This is, in part, due to a shortage of simple, physiologically and clinically relevant test systems for investigating candidate ...
Paredes Roberto, Matthias Augustin, Jennifer E Kloepper, Amaya, Enrique; id_orcid, Roberto Paredes (452874), Pattwell David M., Natalia T. Meier (452870), Enrique Amaya, Matthias Augustin (452876), Haslam Iain S., Augustin Matthias, Paus Ralf, Hardman, Matthew J, Kloepper, Jennifer E, Paus, Ralf, Sebastian Debus, Pattwell, David M., Wolfgang Funk, Matthew J Hardman, Wolfgang Funk (405807), Kloepper Jennifer E., Meier Natalia T., Matthew J. Hardman (452878), Amaya, Enrique, Zhang, Guo You, Amaya Enrique, Debus, Sebastian, Zhang Guo-You, Vladimir Emelianov (452873), Jennifer E. Kloepper (452877), Paredes, Roberto, Emelianov Vladimir, Guo-You Zhang, Sebastian Debus (452875), Hardman Matthew J., Haslam, Iain S., Funk Wolfgang, Hardman, Matthew J., Augustin, Matthias, Pattwell, David M, Kloepper, Jennifer E., Haslam, Iain S, Enrique Amaya (31703), Ralf Paus (261703), Emelianov, Vladimir, Haslam, Iain, Zhang, Guo-You, Natalia T Meier, Debus Sebastian, Meier, Natalia T., Vladimir Emelianov, Iain S Haslam, Roberto Paredes, David M. Pattwell (452872), Ralf Paus, Meier, Natalia T, Guo-You Zhang (397743), Funk, Wolfgang, Iain S. Haslam (452871), David M Pattwell   +59 more
core   +2 more sources

Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. [PDF]

PLoS ONE, 2010
Hormonally-regulated histone modifications that govern positive versus negative transcription of target genes are poorly characterized despite their importance for normal and pathological endocrine function.
Dongqing Wang, Xianmin Xia, Roy E Weiss, Samuel Refetoff, Paul M Yen   +4 more
doaj   +1 more source

Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis [PDF]

Endocrinology and Metabolism
Background Both Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are classified as autoimmune thyroid diseases (AITDs). It has been hypothesized that changes in the thyroid-stimulating hormone receptor (TSHR) gene may contribute to the development ...
Hendra Zufry, Timotius Ivan Hariyanto
doaj   +1 more source

Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [13]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [28].
Gershengorn, Marvin, Davenport, Anthony P., Hills, Rebecca   +2 more
core   +1 more source