Results 211 to 220 of about 10,411 (253)
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Thyrotropin Receptor Antibodies
1981The thyrotropin (TSH) receptor is an integral membrane protein which contains 2 subunits linked by a disulphide bridge. The A subunit (mol. wt. 50,000) is water soluble and forms the binding site for TSH, whereas the B subunit (mol. wt. 30,000) penetrates the lipid bilayer and probably forms the site for interaction with adenylate cyclase ...
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Thyrotropin receptor antibodies.
Arzneimittel-Forschung, 1986The thyrotropin (TSH) receptor is an integral membrane protein which contains 2 subunits linked by a disulphide bridge. The A subunit (mol. wt. 50,000) is water soluble and forms the binding site for TSH, whereas the B subunit (mol. wt. 30,000) penetrates the lipid bilayer and probably forms the site for interaction with adenylate cyclase ...
B, Rees Smith +7 more
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Thyrotropin receptor autoantibodies in Graves' disease
Trends in Endocrinology and Metabolism, 2005Clinical thyrotoxicosis in Graves' disease patients is caused by thyrotropin receptor (TSHR)-stimulating autoantibodies. The molecular mechanisms of TSHR post-translational modification, TSHR signaling and TSHR-autoantibody interaction are still debatable, and the precise interaction of stimulating and blocking autoantibodies with TSHR is unclear ...
Matthias, Schott +2 more
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The Thyrotropin Receptor in Graves' Disease
Thyroid, 2007The application of molecular biology to the study of the thyrotropin receptor (TSHR) has led to major advances in our understanding of its structure, function, and relationship to the pathogenesis of Graves' disease. This review summarizes many of these features and also provides a personal perspective, questioning some assumptions and general concepts,
Basil, Rapoport, Sandra M, McLachlan
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Thyrotropin Receptor in Non-thyroid Tissues
Biochemical and Biophysical Research Communications, 1993Thyrotropin receptor (TSH-R), the main target for the autoantibody in Graves' disease, has been thought to be a thyroid-specific protein. However, we successfully obtained the cDNA fragments of TSH-R from rat retro-orbital tissues and adipose tissues by using polymerase chain reaction methods. Sequencing has revealed that the nucleotide sequence of the
T, Endo +4 more
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Monoclonal Antibodies and the Thyrotropin Receptor
1984Thyrotropin (TSH) is a pituitary glycoprotein hormone whose primary role is to regulate thyroid cell function (Dumont, 1971; Field, 1980; Robbins et al., 1980; Kohn et al., 1983). The interaction of TSH with a specific receptor on the thyroid cell surface induces changes in adenylate cylcase activity which result in the following tissue responses ...
Kohn, Ld +5 more
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Clinical Application of Thyrotropin Receptor Antibodies
Hormone and Metabolic ResearchAbstractThyrotropin receptor antibodies (TRAb) are specific for Graves’ disease (GD) and play a crucial role in the pathogenesis of GD. TRAb assays have recently been greatly improved. This review discusses the clinical application of TRAb in the differential diagnosis of hyperthyroidism, the ...
Yang Yang, Hui Chen
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Hormone- and antibody-mediated activation of the thyrotropin receptor
Nature, 2022Peiyu Xu, Xiaodong Luan, Xin-heng He
exaly
Autoantibody mimicry of hormone action at the thyrotropin receptor
Nature, 2022Bryan Faust +2 more
exaly
The Thyrotropin Receptor and Thyrotropin-Receptor Antibodies
Biochemical Society Transactions, 1979openaire +2 more sources