Results 251 to 260 of about 10,497,311 (290)
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Biochemical and Biophysical Research Communications, 2005
Apoptosis has been attributed an essential role in dilated cardiomyopathy (DCM) recently. We assessed expression of TNF-related apoptosis-inducing ligand (TRAIL) and its decoy receptor osteoprotegerin (OPG) in men with nonischemic DCM, who underwent coronary angiography and endomyocardial biopsy (EMB) after exclusion of coronary artery disease compared
Michael, Schoppet +7 more
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Apoptosis has been attributed an essential role in dilated cardiomyopathy (DCM) recently. We assessed expression of TNF-related apoptosis-inducing ligand (TRAIL) and its decoy receptor osteoprotegerin (OPG) in men with nonischemic DCM, who underwent coronary angiography and endomyocardial biopsy (EMB) after exclusion of coronary artery disease compared
Michael, Schoppet +7 more
openaire +2 more sources
The Journal of Pathology, 2003
AbstractTumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis in tumour cell lines. Four membrane‐bound receptors for TRAIL have been identified, two apoptosis‐mediating receptors, DR4 and DR5, and two apoptosis‐inhibiting receptors, DcR1 and DcR2.
Koornstra, JJ +6 more
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AbstractTumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis in tumour cell lines. Four membrane‐bound receptors for TRAIL have been identified, two apoptosis‐mediating receptors, DR4 and DR5, and two apoptosis‐inhibiting receptors, DcR1 and DcR2.
Koornstra, JJ +6 more
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The International Journal of Biochemistry & Cell Biology, 2007
Cancer is a widespread disease, with half of all men and one-third of all women in the United States developing cancer during their lifetime. The efficacy of many cancer treatments including radiotherapy, chemotherapy and immunotherapy is due to their ability to induce tumor cell apoptosis.
Cretney, Erika +2 more
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Cancer is a widespread disease, with half of all men and one-third of all women in the United States developing cancer during their lifetime. The efficacy of many cancer treatments including radiotherapy, chemotherapy and immunotherapy is due to their ability to induce tumor cell apoptosis.
Cretney, Erika +2 more
openaire +4 more sources
Bone, 2011
Bacteria and their products are potent inducers of bone destruction. While inflammatory damage during conditions such as osteomyelitis is associated with increased formation and activity of bone-resorbing osteoclasts, it is likely that bone loss also results from the elimination of the cells responsible for matrix deposition.
Amy B, Young +3 more
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Bacteria and their products are potent inducers of bone destruction. While inflammatory damage during conditions such as osteomyelitis is associated with increased formation and activity of bone-resorbing osteoclasts, it is likely that bone loss also results from the elimination of the cells responsible for matrix deposition.
Amy B, Young +3 more
openaire +2 more sources
Gene Reports, 2021
Abstract Host genetic factors of apoptotic genes could play an important role in the rapid progression of chronic hepatitis C virus (HCV) infection to liver cirrhosis. This study focused on the role of Tumor Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL) (1525G/A and 1595C/T), TRAIL Death Receptor4 (DR4) (626C/G and 683A/C) and Fas (−670A ...
Roba M. Talaat +4 more
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Abstract Host genetic factors of apoptotic genes could play an important role in the rapid progression of chronic hepatitis C virus (HCV) infection to liver cirrhosis. This study focused on the role of Tumor Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL) (1525G/A and 1595C/T), TRAIL Death Receptor4 (DR4) (626C/G and 683A/C) and Fas (−670A ...
Roba M. Talaat +4 more
openaire +1 more source
Applied Biochemistry and Biotechnology, 2016
TNF-related apoptosis-inducing ligand (TRAIL) is an anticancer agent, which has greater apoptosis inducing capacity, but most of the cancer cells become resistant to TRAIL-induced apoptosis. The combined treatment of TRAIL with natural products could restore the cancer cell sensitivity to recombinant human TRAIL (rhTRAIL) protein and might enhance the ...
Sathishkumar Arumugam +4 more
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TNF-related apoptosis-inducing ligand (TRAIL) is an anticancer agent, which has greater apoptosis inducing capacity, but most of the cancer cells become resistant to TRAIL-induced apoptosis. The combined treatment of TRAIL with natural products could restore the cancer cell sensitivity to recombinant human TRAIL (rhTRAIL) protein and might enhance the ...
Sathishkumar Arumugam +4 more
openaire +2 more sources
Journal of Cancer Research and Clinical Oncology, 2002
TNF-related apoptosis-inducing ligand (TRAIL) and its receptors have recently been known to be responsible for apoptotic signaling molecules in tumor cell lines and tissues. These molecules have been reported to be expressed on merely a transcription level, but not on a protein level.
Shohei, Koyama +2 more
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TNF-related apoptosis-inducing ligand (TRAIL) and its receptors have recently been known to be responsible for apoptotic signaling molecules in tumor cell lines and tissues. These molecules have been reported to be expressed on merely a transcription level, but not on a protein level.
Shohei, Koyama +2 more
openaire +2 more sources
Molecular Immunology, 2010
This study tested the hypothesis that TRAIL could play a role in regulating monocyte migration. TRAIL has been widely studied for its anti-tumor function and signaling mechanisms. Using chemotaxis and mouse air-pouch model analyses, we determined that TRAIL-induced chemotactic migration of THP-1 human leukemia and LPS-primed primary human monocytes as ...
Wei, Wei +7 more
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This study tested the hypothesis that TRAIL could play a role in regulating monocyte migration. TRAIL has been widely studied for its anti-tumor function and signaling mechanisms. Using chemotaxis and mouse air-pouch model analyses, we determined that TRAIL-induced chemotactic migration of THP-1 human leukemia and LPS-primed primary human monocytes as ...
Wei, Wei +7 more
openaire +2 more sources
Cancer research, 1999
Past studies have shown that apoptosis mediated by TNF-related apoptosis-inducing ligand (TRAIL) is regulated by the expression of two death receptors [TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2] and two decoy receptors (TRAIL-R3 and TRAIL-R4) that inhibit apoptosis.
Zhang, X D +5 more
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Past studies have shown that apoptosis mediated by TNF-related apoptosis-inducing ligand (TRAIL) is regulated by the expression of two death receptors [TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2] and two decoy receptors (TRAIL-R3 and TRAIL-R4) that inhibit apoptosis.
Zhang, X D +5 more
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Cancer research, 2000
Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis.
B, Gong, A, Almasan
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Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis.
B, Gong, A, Almasan
openaire +1 more source