Results 81 to 90 of about 10,497,311 (290)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. [PDF]

PLoS ONE, 2014
TNF-alpha-related-apoptosis-inducing-ligand (TRAIL) has been explored as a therapeutic drug to kill cancer cells. Cancer cells in the circulation are subjected to apoptosis-inducing factors.
Siddarth Chandrasekaran, Jocelyn R Marshall, James A Messing, Jong-Wei Hsu, Michael R King   +4 more
doaj   +1 more source

Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma

Journal of Cancer Prevention, 2019
Hispolon has been shown to possess antitumor effects in various cancer cells. However, the underlying mechanisms are not fully understood. In this study, we evaluated the sensitizing effect of hispolon on TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human renal carcinoma cells.Apoptosis was analyzed by using cell-based cytometer.
Jung Mi Yun, Kyoung-jin Min, Taeg Kyu Kwon   +2 more
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Combination of cell immortalization and apoptosis induction to engineer decellularized matrices as bone graft materials [PDF]

, 2013
Infection, trauma or tumors can generate critical bone defects in which the regeneration is compromised, thus necessitating the development of suitable repair strategies.
Bourgine, Paul
core   +1 more source

Identification of the biochemical signalling mechanisms underlying CD40 killing in colorectal cancer cells [PDF]

CD40 is a member of the tumour necrosis factor receptor (TNFR) superfamily and ligation by membrane- presented CD40 ligand (mCD40L), but not soluble agonists, causes extensive apoptosis in malignant epithelial cells, including colorectal carcinoma ...
Mohamed, Albashir
core   +3 more sources

An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma

Molecular Therapy: Nucleic Acids, 2019
Human glioblastoma (GBM) is the most aggressive malignancy of the CNS, with less than 5% survival. Despite great efforts to find effective therapeutics, current options remain very limited.
Sorah Yoon, Xiwei Wu, Brian Armstrong, Nagy Habib, John J. Rossi   +4 more
doaj   +1 more source

Association of TNF-related apoptosis inducing ligand receptor (TRAIL-R) gene polymorphisms in Iranian Azeri patients with multiple sclerosis

Archives of Advances in Biosciences, 2016
Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system with various degrees of axonal damage. The TNF-related apoptosis inducing ligand receptor (TRAIL-R) might be playing an important role in the pathogenesis of MS.
Amir Taghavi, Bita, Hashemi, Mehrdad, Niaei, Gholamreza, Rahmani, Seyed Ali   +3 more
openaire   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source