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Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models [PDF]
Frontiers in PhysiologyMaintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose +7 more
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Experimental and Molecular MedicineThe transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo +3 more
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Special status of iron transfer proteins in the serum of breast cancer patients [PDF]
Discover OncologyCancer cells have a greater requirement for iron because of their continuous and rapid proliferation. To do that, iron homeostasis is altered in cancer cells to meet this excessive demand.
Lama Alhaddad +2 more
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Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma [PDF]
PharmaceuticsBackground/Objectives: Glioblastoma represents a particularly aggressive and fatal type of brain tumor. Peptide-drug conjugates, which offer the promise of traversing the blood-brain barrier to selectively accumulate in tumor tissues and precisely target
Perpetue Bataille Backer +1 more
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Pharmaceutics, 2022 This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur +4 more
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Specific parameters of iron metabolism in tuberculosis
Туберкулез и болезни лёгких, 2021 The review presents data from 55 publications about specific parameters of iron metabolism in the human body including those ill with tuberculosis. It describes processes aimed at isolating iron from pathogens and promoting the acquisition of iron by ...
R. Yu. Аbdullаev +2 more
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Fluids and Barriers of the CNS, 2023 Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a ...
Mikkel Roland Holst +12 more
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Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas
ACS Omega, 2021 Gliomas constitute 80% of malignant brain tumors. The survival rate of patients diagnosed with malignant gliomas is only 34.4%, as seen in both adults as well as children.
Tejaswi Koneru +5 more
semanticscholar +1 more source
Transferrin Receptors in Erythropoiesis
International Journal of Molecular Sciences, 2020 Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron ...
Cyrielle Richard, F. Verdier
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