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Experimental and Molecular MedicineThe transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo +3 more
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Transferrin Receptors in Erythropoiesis [PDF]
International Journal of Molecular Sciences, 2020 Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron ...
Cyrielle Richard, F. Verdier
semanticscholar +4 more sources
Localization of transferrin and transferrin receptors in rat testes. [PDF]
Biology of Reproduction, 1984 One of the major proteins secreted by rat Sertoli cells in culture is a transferrin-like protein (Skinner and Griswold, 1980). The purpose of this study was to quantitate the amount of testicular transferrin in fluids isolated from the testis by the use ...
Steven R. Sylvester, Michael D. Griswold
semanticscholar +3 more sources
Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma [PDF]
PharmaceuticsBackground/Objectives: Glioblastoma represents a particularly aggressive and fatal type of brain tumor. Peptide-drug conjugates, which offer the promise of traversing the blood-brain barrier to selectively accumulate in tumor tissues and precisely target
Perpetue Bataille Backer +1 more
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Special status of iron transfer proteins in the serum of breast cancer patients [PDF]
Discover OncologyCancer cells have a greater requirement for iron because of their continuous and rapid proliferation. To do that, iron homeostasis is altered in cancer cells to meet this excessive demand.
Lama Alhaddad +2 more
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Nanomaterials targeting iron homeostasis: a promising strategy for cancer treatment [PDF]
Frontiers in Bioengineering and BiotechnologyIron is essential for vital cellular processes, including DNA synthesis, repair, and proliferation, necessitating enhanced iron uptake and intracellular accumulation.
Bin Li +4 more
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Study in the iron uptake mechanism of Pasteurella multocida [PDF]
Veterinary ResearchPasteurella multocida infects a wide range of animals, causing hemorrhagic septicemia or infectious pneumonia. Iron is an essential nutrient for growth, colonization, and proliferation of P.
Xiangxiang Shen +5 more
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Serum Soluble Transferrin Receptor and Transferrin Levels among Regular Blood Donors
SciMedicine Journal, 2022 Background: The study evaluated the effects of regular blood donation on serum transferrin and soluble transferrin receptor levels at Wenchi Methodist Hospital.
Samuel K. Appiah +16 more
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Pharmaceutics, 2022 This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur +4 more
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Specific parameters of iron metabolism in tuberculosis
Туберкулез и болезни лёгких, 2021 The review presents data from 55 publications about specific parameters of iron metabolism in the human body including those ill with tuberculosis. It describes processes aimed at isolating iron from pathogens and promoting the acquisition of iron by ...
R. Yu. Аbdullаev +2 more
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