Serum levels of tumor necrosis factor-like cytokine 1A and its receptors, death receptor 3 and decoy receptor 3, in patients with spondyloarthropathies: preliminary results from a cross-sectional study [PDF]
RheumatologyIntroduction Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) is a member of the TNF superfamily of cytokines, involved in regulation of the immune and inflammatory response. Recently, therapies aimed at blockade of the TL1A pathway have shown benefit
Emilia Anna Frąckiel +6 more
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Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]
Revista Brasileira de Ortopedia, 2023 Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira +5 more
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Tumor necrosis factor receptor cross‐talk [PDF]
The FEBS Journal, 2011 Extensive research has been performed to unravel the mechanistic signaling pathways mediated by tumor necrosis factor receptor 1 (TNFR1), by contrast there is limited knowledge on cellular signaling upon activation of TNFR2. Recently published data have revealed that these two receptors not only function independently, but also can influence each other
Petrus J W, Naudé +3 more
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Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling
Biomedicines, 2023 Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher +4 more
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Tumor necrosis factor receptor-associated factors (TRAFs) [PDF]
Oncogene, 2001 Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways. More recently they have also been shown to be signal transducers of Toll/interleukin-1 family members. Six members of the TRAF family have been identified. All TRAF proteins
J R, Bradley, J S, Pober
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Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss [PDF]
Endocrinology and Metabolism, 2013 BackgroundReduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM)
Kwang Kon Kim, Sung Ho Jin, Byung Ju Lee
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Frontiers in Immunology, 2023 Many new immunotherapeutic approaches aim on the stimulatory targeting of receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) using antibodies with intrinsic or conditional agonism.
Olena Zaitseva +4 more
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Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects
Frontiers in Immunology, 2020 Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its engagement of pleiotropic signaling via its two receptors: TNFR1 and
Portia Gough, Ian A. Myles
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Frontiers in Immunology, 2022 Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence
Lidawani Lambuk +9 more
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Comparison the function of Cyprinid herpesvirus 3 encoded two viral tumor necrosis factor receptors
Aquaculture Reports, 2021 To avoid immune surveillance and elimination from the host, many viruses encode homologues of host cytokines and cytokine receptors to regulate the host immune response.
Yaojia Zhou +12 more
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