Results 221 to 230 of about 14,304 (250)

The urokinase receptor and regulation of cell surface plasminogen activation

Cell Differentiation and Development, 1990
Urokinase-type plasminogen activator (u-PA) is a key enzyme involved in migration and invasiveness of cells, both in cancer and in several normal physiological processes (Reich, 1978; Dana et al., 1985; Saksela and Rifkin, 1988; Blasi and Verde, 1990).
Francesco Blasi, CUBELLIS, MARIA VITTORIA, M. Teresa Masucci, Lisbeth B. Møller, David P. Olson, Nina Pedersen, Niels Behrendt, Vincent Ellis, Leif R. Lund, Michael Ploug, Ebbe Rønne, Keld Danø   +11 more
openaire   +3 more sources

Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou, Y, Hayashi, T, Itoh, W, Wang, J, Rui, H, Itoh   +5 more
openaire   +2 more sources

The urokinase plasminogen activator and its receptor

Thrombosis and Haemostasis, 2005
SummaryThe urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis).The proteolytic activity of uPA is ...
Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, Caputi M, Carriero MV, Iaccarino I, Stoppelli MP   +9 more
openaire   +5 more sources

A CELLULAR RECEPTOR FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR

Thrombosis and Haemostasis, 1987
Recent cell biological and biochemical studies on the urokinase-type plasminogen activator (u-PA) have revealed an unsuspected property of this protein: it binds with high affinity and specificity to the plasma membrane of a number of cell types. Hence, while the interaction of tissue-type plasminogen activator (t-PA) with fibrin suggests a preferred ...
Belin, D, Baccino, D, Wohlwend, A, Estreicher, A, Hurate, J, Vassalli, J-D   +5 more
openaire   +2 more sources

Endogenous Arteriolar Fibrinolysis Requires Urokinase Plasminogen Activator and Leukocyte Urokinase Plasminogen Activator Receptor-1.

Blood, 2006
Abstract Background: In venous thrombi, urokinase associated with leukocytes activates plasminogen to initiate endogenous fibrinolysis. Leukocytes also interact with arteriolar thrombi. Objectives: We hypothesized that urokinase plasminogen activator (uPA) activity would also be delivered to arteriolar thrombi by ...
Xufang Bai, Peter L. Gross
openaire   +1 more source

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem, AKINCI, BARIŞ, Yesil, Sena, Tunali, Sunay, Tunc, Ulku Aybuke, Yuksel, Faize, Sevindik, Gokmen   +6 more
openaire   +3 more sources

Characterization of Cell-Associated Plasminogen Activation Catalyzed by Urokinase-Type Plasminogen Activator, but Independent of Urokinase Receptor (uPAR, CD87)

Blood, 1999
The 55-kD urokinase (uPA) receptor (uPAR, CD87) is capable of binding uPA and may be involved in regulating cell-associated plasminogen activation and pericellular proteolysis. While investigating the relationship between uPAR levels and plasmin generation, we found that uPA-catalyzed plasminogen activation is stimulated by cells which do not express ...
C, Longstaff, R E, Merton, P, Fabregas, J, Felez   +3 more
openaire   +2 more sources

Expression of urokinase plasminogen activator receptor in resting and activated bovine neutrophils

Journal of Dairy Research, 2002
Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined. Low amounts of u-PA were found intracellularly or membrane-bound in resting neutrophils.
I. Politis, B. Zavizion, F. Cheli, A. Baldi   +3 more
openaire   +2 more sources

Expression of urokinase-type plasminogen activator receptor in hepatocellular carcinoma

Hepatology, 1997
It is well known that a urokinase-type plasminogen activator receptor (uPAR) is a key protein in the plasminogen activation system, which plays a proteolytically important role in the invasion and metastasis of various cancer cells.
Y, Morita, Y, Hayashi, Y, Wang, T, Kanamaru, S, Suzuki, K, Kawasaki, K, Ohta, M, Yamamoto, Y, Saitoh, H, Itoh, W F, Doe   +10 more
openaire   +2 more sources

Plasminogen Activation by Receptor-Bound Urokinase

Seminars in Thrombosis and Hemostasis, 1991
V, Ellis, K, Danø
openaire   +2 more sources