Pro-Coagulant Lipids in Physiological Ratios Found in the Activated Platelet Membrane Do Not Impact Clot Structure or Fibrinolysis in Purified Assays. [PDF]
J Blood MedMorgan BH +8 more
europepmc +1 more source
Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long-Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study. [PDF]
J Am Heart AssocYadalam AK +5 more
europepmc +1 more source
Reversal of filarial serpin Wb123-urokinase plasminogen activator receptor mediated alternative macrophage activation by monoclonal antibody. [PDF]
PLoS Negl Trop DisUpadhyay P +10 more
europepmc +1 more source
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The receptor for urokinase‐plasminogen activator
Journal of Cellular Biochemistry, 1986AbstractMany human cells and cell lines possess a specific receptor that binds urokinase plasminogen activator (uPA) with an affinity of about 10−10 M. Bound enzyme is not internalized, is slowly dissociated, and retains its enzymatic activity. The amino acid sequence of uPA responsible for receptor binding is located within the first 35 aminoterminal ...
Francesco Blasi +2 more
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Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
International Journal of Cancer, 1995AbstractUrokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane‐bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers.
C, Duggan +5 more
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Regulation of the Urokinase Receptor by Its Plasminogen Activator
Thrombosis and Haemostasis, 1991SummaryThere is now ample evidence that the proteolytic action of urokinase (UK) is potentiated by a specific cell surface receptor. The present study was undertaken to assess the role of UK as a modulator of its receptor. GEO colonic cells, which secrete relatively low levels of UK (≃0.1 nM/72 h per 106 cells) and display approximately 104 receptors ...
W, Hollas, D, Boyd
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Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue.
Sh. Anwar, T. Yanai, H. Sakai
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Role of plasminogen activators and urokinase receptor in platelet kinetics
The Hematology Journal, 2000Plasminogen activators (PA) and plasmin are known to affect platelets but little is known of their role in platelet kinetics. We took advantage of genetically deficient mice to explore the role of urokinase (uPA) and tissue type (tPA) PAs, as well as the uPA receptor (uPAR, CD87) in platelet kinetics.Platelet shape and number were investigated by flow ...
Piguet PF +3 more
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Intermolecular Contact Regions in Urokinase Plasminogen Activator Receptor
Journal of Biochemistry, 2003The glycolipid-anchored urokinase-type plasminogen activator receptor (uPAR) is engaged in various signal transduction events related to cell adhesion, migration and proliferation. In this study, using phage display and peptide array techniques, we have identified several intermolecular contact regions of uPAR.
Olin D, Liang +4 more
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Urokinase plasminogen activator receptor levels in Behcet's disease
Thrombosis Research, 2011To determine urokinase plasminogen activator receptor (uPAR) concentrations in Behcet patients with and without ocular involvement; and to investigate the associations between uPAR levels and clinical manifestations of Behcet's disease.Sixty-four patients with Behcet's disease (31 patients with and 33 patients without ocular involvement) and 23 healthy
Serhat, Birengel +4 more
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