Results 191 to 200 of about 676,629 (244)

Leptospira glyceraldehyde-3-phosphate dehydrogenase (LiGAPDH): a cell-surface plasminogen binding protein. [PDF]

FEMS Microbiol Lett
de Souza MCL, Nepomuceno R, Santos CM, Abe CM, Barbosa AS.   +4 more
europepmc   +1 more source

Sotagliflozin, suPAR, and Cardiovascular Outcomes in Patients With Diabetes and Heart Failure: A SOLOIST-WHF Ancillary Study. [PDF]

J Card Fail
Ismail A, Erne G, Vasbinder A, Hutten CG, Ghazzal BZ, Pizzo I, Diaz KM, Catalan TC, Farhat T, Knott B, Kunkle P, Szarek M, Davies MJ, Steg PG, Pitt B, Bhatt DL, Hayek SS.   +16 more
europepmc   +1 more source

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

Circulation, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Stefan Lorenzl, Elisabeth Deindl, Bernd Uhl   +2 more
exaly   +2 more sources

UVB Increases Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression1 [PDF]

Journal of Investigative Dermatology, 1999
Keratinocytes synthesize and secrete urokinase-type plasminogen activator, which binds to its specific receptor on keratinocytes. When bound to urokinase-type plasminogen activator receptor, urokinase-type plasminogen activator proteolytically converts ...
Ernst Lengyel, Viktor Magdolen, Klaus Degitz   +2 more
exaly   +2 more sources

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The receptor for urokinase‐plasminogen activator

Journal of Cellular Biochemistry, 1986
AbstractMany human cells and cell lines possess a specific receptor that binds urokinase plasminogen activator (uPA) with an affinity of about 10−10 M. Bound enzyme is not internalized, is slowly dissociated, and retains its enzymatic activity. The amino acid sequence of uPA responsible for receptor binding is located within the first 35 aminoterminal ...
Francesco Blasi, M. Patrizia Stoppelli, CUBELLIS, MARIA VITTORIA   +2 more
openaire   +3 more sources

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

International Journal of Cancer, 1995
AbstractUrokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane‐bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers.
C, Duggan, T, Maguire, E, McDermott, N, O'Higgins, J J, Fennelly, M J, Duffy   +5 more
openaire   +2 more sources

Regulation of the Urokinase Receptor by Its Plasminogen Activator

Thrombosis and Haemostasis, 1991
SummaryThere is now ample evidence that the proteolytic action of urokinase (UK) is potentiated by a specific cell surface receptor. The present study was undertaken to assess the role of UK as a modulator of its receptor. GEO colonic cells, which secrete relatively low levels of UK (≃0.1 nM/72 h per 106 cells) and display approximately 104 receptors ...
W, Hollas, D, Boyd
openaire   +2 more sources

Immunohistochemical Detection of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor in Canine Vascular Endothelial Tumours

Journal of Comparative Pathology, 2015
Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue.
Sh. Anwar, T. Yanai, H. Sakai
openaire   +2 more sources

Role of plasminogen activators and urokinase receptor in platelet kinetics

The Hematology Journal, 2000
Plasminogen activators (PA) and plasmin are known to affect platelets but little is known of their role in platelet kinetics. We took advantage of genetically deficient mice to explore the role of urokinase (uPA) and tissue type (tPA) PAs, as well as the uPA receptor (uPAR, CD87) in platelet kinetics.Platelet shape and number were investigated by flow ...
Piguet PF, Vesin C, Da Laperousaz C, Rochat A   +3 more
openaire   +3 more sources

Intermolecular Contact Regions in Urokinase Plasminogen Activator Receptor

Journal of Biochemistry, 2003
The glycolipid-anchored urokinase-type plasminogen activator receptor (uPAR) is engaged in various signal transduction events related to cell adhesion, migration and proliferation. In this study, using phage display and peptide array techniques, we have identified several intermolecular contact regions of uPAR.
Olin D, Liang, Khalil, Bdeir, Rachel L, Matz, Triantafyllos, Chavakis, Klaus T, Preissner   +4 more
openaire   +2 more sources