Results 281 to 290 of about 10,420,356 (335)

Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung

Critical Care Medicine, 2005
Vascular endothelial growth factor (VEGF) regulates vascular proliferation and causes vasodilation. In the pulmonary circulation, the vasorelaxing effect of VEGF has been attributed to nitric oxide, whereas in other vascular beds, prostacyclin and other mechanisms are also involved. This vascular effect follows binding to two receptors, VEGF receptor 1
Annie, Janvier, Sophie, Nadeau, Johanne, Baribeau, Thérèse, Perreault   +3 more
openaire   +2 more sources

Modulation of vascular endothelial growth factor receptors in melanocytes

Experimental Dermatology, 2005
Abstract:  Vascular endothelial growth factor (VEGF) is constitutively produced by keratinocytes, but has no known epidermal target cell. We now report that normal human melanocytes (Mc) maintained in serum‐free, hormone‐, and growth factor‐supplemented medium lacking phorbol ester and choleragen constitutively express VEGF receptor‐1 (VEGFR‐1), VEGFR ...
Ellen J, Kim, Hee-Young, Park, Mina, Yaar, Barbara A, Gilchrest   +3 more
openaire   +2 more sources

Vascular Endothelial Growth Factor Receptor-3

1999
Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine ...
J, Taipale, T, Makinen, E, Arighi, E, Kukk, M, Karkkainen, K, Alitalo   +5 more
openaire   +2 more sources

Angiosarcoma of the breast and vascular endothelial growth factor receptor.

Tumori, 2011
Breast angiosarcoma is rare and often associated with previous breast cancer treatment. The present study aimed to define long-term outcomes in relation to common prognostic factors. The expression of vascular endothelial growth factor receptor was also evaluated, as it may be a potential target for anti-angiogenic therapy.We retrospectively assessed ...
Massimiliano Gennaro, Barbara Valeri, Patrizia Casalini, Maria Luisa Carcangiu, Alessandro Gronchi, Alberto Rudy Conti, Roberto Agresti, Marco Greco   +7 more
openaire   +2 more sources

Inhibitors of the vascular endothelial growth factor receptor

Hematology/Oncology Clinics of North America, 2002
The inhibitors of VEGF-mediated signaling continue to wind their way through extensive preclinical and clinical development paths. Whereas the first phase III trial did not meet its endpoints, one hopes that the others will. As we learn more about the VEGF pathways in the laboratory and the clinic, we can interpret with greater certainty what role ...
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The vascular endothelial growth factor family and its receptors

Hematology/Oncology Clinics of North America, 2004
This article focuses on describing the biology of vascular endothelial growth factor (VEGF) and its receptors as well as the regulation of their expression. A thorough understanding of the VEGF system is paramount in optimizing antiangiogenic therapies as a component of antineoplastic regimens.
Alexander A, Parikh, Lee M, Ellis
openaire   +2 more sources

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain

Neuroscience, 2015
Increased understanding of the neurovascular niche suggests that development of the central nervous system (CNS) and its vasculature is coordinated through shared regulatory factors. These include the vascular endothelial growth factor (VEGF) family, reported to promote neuroproliferation and neuroprotection in addition to angiogenesis via its ...
M C, Ward, A M, Cunningham
openaire   +2 more sources

Immunohistochemical Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor in Canine Cutaneous Fibrosarcomas

Journal of Comparative Pathology, 2009
The expression of five markers associated with tumour angiogenesis, proliferation and apoptosis was studied in 24 canine cutaneous fibrosarcomas. Tumours were assigned histological grades and were immunohistochemically evaluated for the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2 ...
A N, Al-Dissi, D M, Haines, B, Singh, B A, Kidney   +3 more
openaire   +2 more sources

Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain

Brain Research, 2002
Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the ...
NICO, Beatrice, CORSI, Patrizia, RIBATTI, Domenico, VACCA, Angelo, RONCALI L.   +4 more
openaire   +2 more sources

Vascular Endothelial Growth Factor and Type 2 Receptor for This Factor in Vascular Malformations

Bulletin of Experimental Biology and Medicine, 2011
Immunohistochemical study revealed higher level of VEGF expression in vascular malformations compared to that in normal vessels of the adjacent tissue. VEGF expression was slightly higher in the endothelium of arteriovenous angiodysplasias than in venous angiodysplasias.
K A, Pavlov, E S, Gershtein, E A, Dubova, A I, Shchegolev   +3 more
openaire   +2 more sources