Results 291 to 300 of about 10,420,356 (335)

Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells and a decreased expression of lung vascular endothelial growth factor (VEGF) and its receptor 2 (VEGF R2).
Y, Kasahara, R M, Tuder, C D, Cool, D A, Lynch, S C, Flores, N F, Voelkel   +5 more
openaire   +2 more sources

Increased Vascular Endothelial Growth Factor and Receptors

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Increased vascularity is a feature of airway remodeling in asthma with the potential to contribute to a number of functional abnormalities in this chronic disease. Although various growth factors have been implicated in modulating vascularity, the important contributors in ...
Bryce N. Feltis, Dharshini Wignarajah, Ling Zheng, Chris Ward, David Reid, Richard Harding, E. Haydn Walters   +6 more
openaire   +1 more source

Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

Critical Reviews in Oncology/Hematology, 2000
Angiogenesis, formation of new vessels from pre-existing ones, results from stimulation of endothelial cells, which line the vessel wall. These cells will leave their resting state and start to digest the basement membrane, proliferate, migrate and eventually differentiate to form a hollow tube. All these steps can be induced by growth factors and this
P, Gerwins, E, Sköldenberg, L, Claesson-Welsh   +2 more
openaire   +2 more sources

[Expression of pulmonary vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema].

Zhonghua nei ke za zhi, 2006
To investigate the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) in lung tissues of emphysema patients.The peripheral lung tissues were obtained from 35 patients undergoing pneumonectomy.
Yue-hong, Wang, Chun-xue, Bai, Ling, Mao, Min, Zhang   +3 more
openaire   +1 more source

Vascular Endothelial Growth Factor (VEGF) Receptors

1995
Abstract Two tyrosine kinases have been recently identified as putative VEGF receptors (deVries et al. 1992; Terman et al. 1992a). The flt-1 (fms-like-tyrosine kinase; Shibuya et al. 1990) and KOR (kinase domain region; Terman et al. 1991) proteins have been shown to bind VEGF with high affinity.
J E Park, N Ferrara
openaire   +1 more source

Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 Expression in the Chick Embryo Area Vasculosa

The Histochemical Journal, 2001
Vascular endothelial growth factor is an angiogenic factor in vivo and in vitro that plays a crucial role in the control of blood vessel development and in pathological angiogenesis. The vascularized extraembryonic membranes of the chick embryo include the area vasculosa and the chorioallantoic membrane. In this study, we investigated the expression of
NICO, Beatrice, VACCA, Angelo, DE GIORGIS M, RONCALI L, RIBATTI, Domenico   +4 more
openaire   +2 more sources

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.

Journal of Clinical Oncology, 2005
D. Hicklin, L. Ellis
semanticscholar   +1 more source

Inhibitors of Vascular Endothelial Growth Factor Receptor

2017
Angiogenesis-targeting agents, predominantly inhibitors of vascular endothelial growth factor and its receptors, have become a mainstay in oncology practice over the last decade. The approved drugs, which include two antibodies and seven small molecule inhibitors, represent strong validation for the field of anti-angiogenesis in the treatment of cancer.
openaire   +1 more source

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer.

Human Pathology, 1995
L. F. Brown, B. Berse, R. Jackman, K. Tognazzi, A. Guidi, H. Dvorak, D. Senger, J. Connolly, S. Schnitt   +8 more
semanticscholar   +1 more source

A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis.

Cancer research, 2002
Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We
T P, Quinn, S J, Soifer, K, Ramer, L T, Williams, M C, Nakamura   +4 more
openaire   +1 more source