Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Endothelial cell injury, induced by dyslipidemia, is the initiation of atherosclerosis, resulting in an imbalance in endothelial fatty acid (FA) transport. Pigment epithelial‐derived factor (PEDF) is an important regulator in lipid metabolism.
Haiping Wang +15 more
doaj +1 more source
Journal of Biological Chemistry, 1996 Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli. VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors,
B. Keyt +6 more
semanticscholar +1 more source
Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]
World Cancer Research Journal, 2021 OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj +1 more source
Examining the role of insulin in the regulation of cardiovascular health [PDF]
, 2013 A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
Journal of Cell Biology, 2007 Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can
S. Ball, C. Shuttleworth, C. Kielty
semanticscholar +1 more source
Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor [PDF]
Frontiers in Cell and Developmental Biology, 2021 Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction. Here we evaluated whether the ability of Gal3 to function as an angiogenic factor involved vascular endothelial growth factor (VEGF).
Issahy Cano +14 more
openaire +3 more sources
Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
Molecular Cancer, 2003 As with other solid tumors, the growth and metastasis of pancreatic cancer is critically dependent on tumor angiogenesis. A major stimulus for a tumor's recruitment of additional blood vessels is cellular hypoxia, a condition which is especially ...
Reber Howard A +3 more
doaj +1 more source
Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
core +1 more source
Anlotinib: A Novel Targeted Drug for Bone and Soft Tissue Sarcoma
Frontiers in Oncology, 2021 Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas, each of which is notably heterogeneous and manifested by remarkable phenotypic
Shenglong Li, Shenglong Li
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Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]
, 2018 Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella +13 more
core +2 more sources