Results 41 to 50 of about 666,578 (361)

The effect of all-trans retinoic acid (ATRA) on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors of human colon cancer LoVo cell line [PDF]

, 2013
All-trans retinoic acid (ATRA) was found to inhibit cell growth, induce differentiation and enhance apoptosis in a variety of malignant solid tumors. Retinoic acid is effective in inhibiting the expression of vascular endothelial growth factor (VEGF) in ...
Fucheng, Z, Guili, C, Hongbo, W, Jianglong, H, Tufeng, C, Weiping, G, Yong, H, Zongheng, Z   +7 more
core   +2 more sources

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

Journal of Biological Chemistry, 1996
Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli. VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors,
B. Keyt, H. V. Nguyen, L. Berleau, Carlos M. Duarte, Jeanie Park, Helen Chen, N. Ferrara   +6 more
semanticscholar   +1 more source

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells [PDF]

Journal of Biological Chemistry, 1995
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and endothelial cell-specific mitogen that stimulates urokinase-type plasminogen activator (uPA) activity in vascular endothelial cells. Here, we report that VEGF increases the high affinity binding of uPA to the same cells and that this binding is prevented by a peptide ...
Mandriota, Stephano J., Seghezzi, Graziano, Vassalli, Jean-Dominique, Ferrara, Napoleone, Wasi, Safia, Mazzieri, Roberta, Mignatti, Paolo, Pepper, Michael S.   +7 more
openaire   +5 more sources

Anlotinib: A Novel Targeted Drug for Bone and Soft Tissue Sarcoma

Frontiers in Oncology, 2021
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas, each of which is notably heterogeneous and manifested by remarkable phenotypic
Shenglong Li, Shenglong Li
doaj   +1 more source

A peptide corresponding to the neuropilin-1-binding site on VEGF165 induces apoptosis of neuropilin-1-expressing breast tumour cells [PDF]

, 2005
There is increasing evidence that vascular endothelial growth factor (VEGF) has autocrine as well as paracrine functions in tumour biology. Vascular endothelial growth factor-mediated cell survival signalling occurs via the classical tyrosine kinase ...
B Millauer, B Rohm, DH Gorski, F Yuan, GP Pidgeon, H Fujisawa, J Folkman, J Harmey, J Waltenberger, KG Peters, KJ Kim, L Tae-Hee, L Tamagnone, L Xu, ML Gagnon, PC Singhal, R Binetruy-Tournaire, R Mamluk, RE Bachelder, RE Bachelder, RE Bachelder, S Soker, S Soker, S Soker, T Takahashi, Z Gluzman-Poltorak   +25 more
core   +2 more sources

Abl family kinases regulate endothelial barrier function in vitro and in mice. [PDF]

PLoS ONE, 2013
The maintenance of endothelial barrier function is essential for normal physiology, and increased vascular permeability is a feature of a wide variety of pathological conditions, leading to complications including edema and tissue damage.
Elizabeth M Chislock, Ann Marie Pendergast   +1 more
doaj   +1 more source

Breaking the VE-cadherin bonds [PDF]

FEBS Letters / FEBS-Letters; FEBS Microbiol Lett (2008) epub ahead of print, 2008
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing
arxiv   +1 more source

Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

Journal of Clinical Investigation, 1993
Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen. To evaluate whether VEGF may play a role in angiogenesis, we have determined the spatial and temporal patterns of expression of VEGF and VEGF receptors during ...
D. Shweiki, A. Itin, G. Neufeld, H. Gitay-Goren, E. Keshet   +4 more
semanticscholar   +1 more source

Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports

Journal of Medical Case Reports, 2018
Background Renal cell carcinoma represents 3–5% of adult malignant tumors. Metastases are found in 30–40% of patients and brain metastases occurred in more than 10% of them.
Sylvie Négrier, Guillaume Moriceau, Valéry Attignon, Véronique Haddad, Daniel Pissaloux, Nicole Guerin, Christian Carrie   +6 more
doaj   +1 more source

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source