Results 21 to 30 of about 14,521 (208)
Molecules, 2017 Many synthetic peptides have been developed for diagnosis and therapy of human cancers based on their ability to target specific receptors on cancer cell surface or to penetrate the cell membrane.
Anna Lucia Tornesello +3 more
doaj +1 more source
Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Frontiers in Endocrinology, 2021 Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj +1 more source
Frontiers in Pharmacology, 2016 Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma ...
Grazia eMaugeri +7 more
doaj +1 more source
Vasoactive intestinal peptide receptor activity in human fetal enterocytes
FEBS Letters, 1985 Functional and specific receptors for vasoactive intestinal peptide (VIP) (determined by their capacity to bind 125I‐VIP and activate adenylate cyclase) and cyclic AMP‐dependent phosphodiesterase activities were characterized in enterocytes of human fetal small intestine between 18 and 23 weeks of gestation.
Gespach, Christian +3 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2020 Vasoactive intestinal peptide (VIP) is an important modulatory peptide throughout the CNS acting as a neurotransmitter, neurotrophic or neuroprotective factor.
Diana Cunha-Reis +3 more
doaj +1 more source
Targeting VIP and PACAP Receptor Signalling: New Therapeutic Strategies in Multiple Sclerosis
ASN Neuro, 2011 MS (multiple sclerosis) is a chronic autoimmune and neurodegenerative pathology of the CNS (central nervous system) affecting approx. 2.5 million people worldwide. Current and emerging DMDs (disease-modifying drugs) predominantly target the immune system.
Yossan-Var Tan, James A Waschek
doaj +1 more source
Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway
Brazilian Journal of Medical and Biological Research, 2018 We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway ...
A.K.M. Cavalcante +5 more
doaj +1 more source
The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease
Endocrines, 2023 The communication between brain and peripheral tissues is mediated by neuropeptides that coordinate the functions of each organ with the activities of the entire body in specific environmental conditions.
Anca D. Petrescu +4 more
doaj +1 more source
Advanced Science, EarlyView.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance
Frontiers in Endocrinology, 2019 The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins.
Rosa P. Gomariz +9 more
doaj +1 more source