Results 41 to 50 of about 14,916 (199)

Targeting Inflammation Driven by HMGB1 in Bacterial Keratitis—A Review

Pathogens, 2021
Pseudomonas (P.) aeruginosa is a Gram-negative bacteria that causes human infections. It can cause keratitis, a severe eye infection, that develops quickly and is a major cause of ulceration of the cornea and ocular complications globally.
Linda D. Hazlett, Sharon McClellan, Mallika Somayajulu, Denise Bessert   +3 more
doaj   +1 more source

Processionary Moth Exposure in Europe: Toxic–Irritant and Immunoglobulin E‐Mediated Endotypes, Diagnosis and Management

Clinical &Experimental Allergy, EarlyView.
Most reactions are toxic–irritant, driven by epithelial injury and neuro‐inflammatory activation. IgE‐mediated allergy is less common but may cause immediate systemic reactions. Endotype differentiation guides diagnosis, risk stratification and management.
Prasad Dasari, Josefine Haas, Wolfgang Rohe, Kai Gloyna, Christoph Viebahn, Susann Forkel, Michael Szardenings, Christine Stadelmann, Michael P. Schön, Timo Buhl   +9 more
wiley   +1 more source

From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment

Cells, 2023
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides.
Masaru Tanaka, Ágnes Szabó, Tamás Körtési, Délia Szok, János Tajti, László Vécsei   +5 more
doaj   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders

Molecules
The interaction between the neuroendocrine system and the immune system plays a key role in the onset and progression of various diseases. Neuropeptides, recognized as common biochemical mediators of communication between these systems, are receiving ...
Kaiqi Chen, Xiaojun Wu, Xiaoke Li, Haoxuan Pan, Wenhui Zhang, Jinxi Shang, Yinuo Di, Ruonan Liu, Zhaodi Zheng, Xitan Hou   +9 more
doaj   +1 more source

Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models

Frontiers in Neuroscience, 2021
Pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) is a multifunctional neuropeptide involved in brain development and synaptic plasticity.
Yukio Ago, Satoshi Asano, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, James A. Waschek   +6 more
doaj   +1 more source

Multiscale analysis of the adult human superior hypogastric plexus and hypogastric nerve

Journal of Anatomy, EarlyView.
Using tissue clearing and light‐sheet microscopy methods, we visualized the 3D mesoscopic arrangement of neural tracts, blood vessels and neurons within the adult human superior hypogastric plexus and hypogastric nerves, identifying the latter to contain thousands of neuronal cells bodies embedded along its entire length.
Kayleigh S. Scotcher, John‐Paul Fuller‐Jackson, Peregrine B. Osborne, Martin M. Bertrand, Janet R. Keast   +4 more
wiley   +1 more source

Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer

Theranostics, 2012
Human cancer cells overexpress many peptide receptors as molecular targets. Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor cells hold great potential for both diagnostic imaging and targeted radionuclide ...
M. Fani, H. R. Maecke, S. M. Okarvi
doaj  

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells

Cells
Microglial cells, the resident immune cells of the central nervous system (CNS), are essential for maintaining CNS homeostasis. Dysregulation of microglial function is implicated in the pathogenesis of various neurodegenerative diseases.
Xin Ying Rachel Song, Margo Iris Jansen, Rubina Marzagalli, Giuseppe Musumeci, Velia D’Agata, Alessandro Castorina   +5 more
doaj   +1 more source

Dietary L‐Tyrosine Sustains Egg Production and Quality by Modulating Promoter CpG Methylation, Gene Expression, and Hormone Profiles in Reproductive Signalling Pathways of Aged Laying Hens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Managing prolactin (PRL)‐mediated reproductive suppression is critical for maintaining egg production in commercial laying hens. L‐tyrosine (TYR), a precursor of dopamine (DA), may counteract age‐related reproductive decline by suppressing PRL, thereby sustaining productivity and egg quality in late‐phase laying hens.
Hasan Hüseyin İpçak
wiley   +1 more source