Results 41 to 50 of about 15,888 (236)
Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors
Frontiers in Endocrinology, 2021 Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj +1 more source
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine +5 more
core +1 more source
Frontiers in Pharmacology, 2016 Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma ...
Grazia eMaugeri +7 more
doaj +1 more source
Targeting VIP and PACAP Receptor Signalling: New Therapeutic Strategies in Multiple Sclerosis
ASN Neuro, 2011 MS (multiple sclerosis) is a chronic autoimmune and neurodegenerative pathology of the CNS (central nervous system) affecting approx. 2.5 million people worldwide. Current and emerging DMDs (disease-modifying drugs) predominantly target the immune system.
Yossan-Var Tan, James A Waschek
doaj +1 more source
Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway
Brazilian Journal of Medical and Biological Research, 2018 We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway ...
A.K.M. Cavalcante +5 more
doaj +1 more source
The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease
Endocrines, 2023 The communication between brain and peripheral tissues is mediated by neuropeptides that coordinate the functions of each organ with the activities of the entire body in specific environmental conditions.
Anca D. Petrescu +4 more
doaj +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Mediators of Inflammation, 2008 Vasoactive neuropeptides (VNs) such as pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, as well as immune
D. R. Staines +2 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
High expression of peptide receptors as a novel target in gastrointestinal stromal tumours [PDF]
, 2004 Recent significant advances in understanding the biology of gastrointestinal stromal tumours (GIST) have led to the introduction of a new targeted therapy (imatinib mesylate, Glivec).
Mazzucchelli, L. +9 more
core +1 more source