Results 71 to 80 of about 14,521 (208)

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies

Frontiers in Pharmacology
Osteoporosis (OP) is a complex bone metabolism disorder disease that affects the skeleton, nervous system, muscles, and multiple tissues. Neuropeptides, which are endogenous substances derived from both bone and brain, play a critical role in maintaining
Qing Lin, Qing Lin, Biyi Zhao, Jiajia Huang, Rumeng Chen, Weipeng Sun, Qianyun Ye, Qianyun Ye, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Xiaofeng Zhu, Xiaoyun Li, Xiaoyun Li, Ronghua Zhang, Ronghua Zhang   +16 more
doaj   +1 more source

Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler Mice Compared to Controls

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
In the habituation task, locomotion speed, whisker angular position and whisker spread decreased between the first two consecutive sessions in all mice, suggesting that the animals were less focused on sampling the area as they got more familiar with the environment.
Ugne Simanaviciute, Aybeniz Ece Cetin, Julien Guy, Helen Tams, Jochen Staiger, Robyn A. Grant   +5 more
wiley   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function

Frontiers in Endocrinology, 2018
Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol, Toon Laeremans, Toon Laeremans, Toon Laeremans, Vannessa Lahura, Maja Debulpaep, Maja Debulpaep, Maja Debulpaep, Hassan El Hassan, Hassan El Hassan, Hassan El Hassan, Jan Steyaert, Jan Steyaert, Marc Parmentier, Marc Parmentier, Ingrid Langer   +15 more
doaj   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

The Anti-Inflammatory Mediator, Vasoactive Intestinal Peptide, Modulates the Differentiation and Function of Th Subsets in Rheumatoid Arthritis

Journal of Immunology Research, 2018
Genetic background, epigenetic modifications, and environmental factors trigger autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been related to the onset of RA and may cause an inadequate immunological tolerance ...
Raúl Villanueva-Romero, Irene Gutiérrez-Cañas, Mar Carrión, Selene Pérez-García, Iria V. Seoane, Carmen Martínez, Rosa P. Gomariz, Yasmina Juarranz   +7 more
doaj   +1 more source

Characterization of vasoactive intestinal peptide receptors by a photoaffinity label. Site-specific modification of vasoactive intestinal peptide by derivatization of the receptor-bound peptide.

Journal of Biological Chemistry, 1987
The biological effects of vasoactive intestinal peptide (VIP) are mediated by binding to a membrane-bound receptor. Probes designed to trap this receptor by binding to it in a covalent way may suffer from a greatly reduced affinity. We report here, for the VIP receptor, the use of a photoaffinity probe obtained by derivatization of receptor-bound VIP ...
A, Robichon, P F, Kuks, J, Besson
openaire   +2 more sources

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Sex and life experience shape locus coeruleus pretangle tau pathology

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease features early a pathology in the locus coeruleus (LC), yet how sex and life experience shape LC vulnerability remains poorly understood. METHODS We expressed pseudophosphorylated human tau (htauE14) in LC neurons of TH‐Cre rats and exposed both sexes to early‐ or late‐life enrichment or stress.
Zia Hasan, Sarah E. Torraville, Tamunotonye Omoluabi, Aida Maziar, Onyedikachi N. Belolise, Lauren A. MacGowan, Cassandra M. Flynn, Camila Reinhardt, Susan G. Walling, Touati Benoukraf, Qi Yuan   +10 more
wiley   +1 more source