Results 81 to 90 of about 14,916 (199)

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders

Experimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley   +1 more source

The Anti-Inflammatory Mediator, Vasoactive Intestinal Peptide, Modulates the Differentiation and Function of Th Subsets in Rheumatoid Arthritis

Journal of Immunology Research, 2018
Genetic background, epigenetic modifications, and environmental factors trigger autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been related to the onset of RA and may cause an inadequate immunological tolerance ...
Raúl Villanueva-Romero, Irene Gutiérrez-Cañas, Mar Carrión, Selene Pérez-García, Iria V. Seoane, Carmen Martínez, Rosa P. Gomariz, Yasmina Juarranz   +7 more
doaj   +1 more source

Interaction of a bovine thymic peptide extract with vasoactive intestinal peptide (VIP) receptors

Bioscience Reports, 1986
Bovine t hymic peptide extract (1–100 μg/ml) is shown to completely inhibit the binding of [125I]VIP to rat blood mononuclear cells, lymphoid cells of spleen, and liver plasma membranes. In the three models, the bovine thymic peptide extract inhibits [125I]VIP binding with a potency that is 4000–7000 times lower than that of the native VIP, on a weight
J M, Guerrero, R, Goberna, P, Molinero, J, Jimenez, J R, Calvo   +4 more
openaire   +2 more sources

Procedure‐specific morbidity and pathologic assessment after resection of small (≤20 mm) pancreatic neuroendocrine tumors

Journal of Neuroendocrinology, Volume 38, Issue 8, August 2026.
Abstract Pancreatic neuroendocrine tumors (PanNETs) are increasingly detected, and the optimal extent of resection remains uncertain because perioperative burden and oncologic assessment may differ by procedure. Enucleation (EN) and central pancreatectomy (CP) are often grouped together as parenchyma‐sparing resections (PSRs) despite substantial ...
Aya Maekawa, Giampaolo Perri, Stefano Partelli, Charles de Ponthaud, Safi Dokmak, Carsten Jäger, Maria Lavinia Luzietti, Alessio Marchetti, Valentina Andreasi, Anna Battistella, Bengi Su Yilmaz, Andrea Sheel, Kunal Rajput, Haiyi Hu, Umberto Cillo, Alain Sauvanet, Helmut Friess, Ryan D. Baron, Sébastien Gaujoux, Massimo Falconi, Giovanni Marchegiani   +20 more
wiley   +1 more source

Vasoactive intestinal peptide receptor-based imaging and treatment of tumors

International Journal of Oncology, 2014
Vasoactive intestinal peptide receptors (VIPRs) are members of the G-protein-coupled receptor superfamily. These receptors are overexpressed in many common malignant tumors and play a major role in the progression and angiogenesis of a number of malignancies.
Bo, Tang, Xin, Yong, Rui, Xie, Qian-Wei, Li, Shi-Ming, Yang   +4 more
openaire   +3 more sources

Characterization of global and region‐specific transcriptomic alterations in the bladder following acute partial bladder outlet obstruction in female mini‐swine

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Partial bladder outlet obstruction (pBOO) is a fibroproliferative disorder that results in poorly compliant, high‐pressure bladders due to lower urinary tract occlusion. The mechanisms governing pBOO‐induced bladder remodeling remain poorly understood.
Yi Xi Wu, Gokhan Gundogdu, Madison Rivero, Caila Ruiz‐May, Ahmet Tarik Gundogdu, Victor Pham, Keith Rourke, Zhina Sadeghi, Joel Gelman, Joshua R. Mauney   +9 more
wiley   +1 more source

Pituitary adenylate cyclase‐activating polypeptide targeted treatments in primary headache disorders

Annals of Clinical and Translational Neurology
Objective Migraine is a complex and disabling neurological disorder. Recent years have witnessed the development and emergence of novel treatments for the condition, namely those targeting calcitonin gene‐related peptide (CGRP).
Nazia Karsan, Lars Edvinsson, Laszlo Vecsei, Peter J Goadsby   +3 more
doaj   +1 more source

Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

Gut and Liver, 2016
Background/AimsPrevious studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS).
doaj   +1 more source