Results 51 to 60 of about 4,110,019 (315)
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors
Nature Communications, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV).
Preston S K Ng +14 more
semanticscholar +1 more source
BiomoleculesViruses are obligate intracellular parasites that rely on cell surface receptor molecules to complete the first step of invading host cells. The experimental method for virus receptor screening is time-consuming, and receptor molecules have been ...
Yang Sun +8 more
doaj +1 more source
Specificity switching in virus–receptor complexes [PDF]
Current Opinion in Structural Biology, 2009 Several structures of complexes between viral attachment proteins and their cellular receptors have been determined recently, enhancing our understanding of the molecular recognition processes that guide formation of virus-receptor complexes. Moreover, these structures also highlight strategies by which highly similar viral proteins within a single ...
Thilo Stehle +2 more
openaire +3 more sources
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
Proceedings of the National Academy of Sciences of the United States of America, 2013 Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy ...
Danit Finkelshtein +4 more
semanticscholar +1 more source
Anti-virus Autobots: Predicting More Infectious Virus Variants for Pandemic Prevention through Deep Learning [PDF]
arXiv, 2022 More infectious virus variants can arise from rapid mutations in their proteins, creating new infection waves. These variants can evade one's immune system and infect vaccinated individuals, lowering vaccine efficacy. Hence, to improve vaccine design, this project proposes Optimus PPIme - a deep learning approach to predict future, more infectious ...
arxiv
The 3.8 Å resolution cryo-EM structure of Zika virus
Science, 2016 Unveiling the Zika virus The ongoing Zika virus epidemic is of grave concern because of its apparent links to congenital microcephaly and Guillain-Barré syndrome. Sirohi et al. present a near-atomic-resolution structure of mature Zika virus determined by
Devika Sirohi +6 more
semanticscholar +1 more source
Receptors for Hepatitis C Virus
Journal of Virology, 2000 The nature of the receptors enabling hepatitis C virus (HCV) entry into cells has been the subject of debate. On one hand, ligand panning with recombinant HCV envelope protein has identified CD81, a member of the tetraspanin superfamily of proteins, as a direct ligand for the E2 glycoprotein (7) but fails to explain virus tropism.
Ian M. Jones +3 more
openaire +4 more sources
Journal of Virology, 2012 Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade.
S. Jensen, A. Thomsen
semanticscholar +1 more source
The epidermal growth factor receptor is not a receptor for vaccinia virus [PDF]
Journal of Virology, 1994 It has been suggested that the epidermal growth factor receptor (EGFR) is a receptor for vaccinia virus. Other reports, although not specifically addressing this question, did not support such a role for the EGFR. We addressed this issue by using wild-type virus and a virus growth factor deletion mutant, as well as sets of cells that do not express ...
A W Hügin, C Hauser
openaire +3 more sources
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Viruses, 2019 Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.
V. Cagno +3 more
semanticscholar +1 more source