Results 91 to 100 of about 574,921 (308)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Construction of gene recombinant IgG1 κ anti-P plasmids and their expression in HEK293T Cells

Zhongguo shuxue zazhi
[Objective] To construct gene recombinant expression plasmids of human anti-P antibody with IgG1 and kappa chain based on the human hybridoma cell line.
GUO Zhonghui, ZHANG Jiamin, ZHU Xinyi, YANG Ying, ZHU Ziyan   +4 more
doaj   +1 more source

Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats

Toxins, 2019
Botulinum neurotoxins (BoNT) are potential biothreat agents due to their high lethality, potency, and ease of distribution, thus the development of antitoxins is a high priority to the US government.
Yero Espinoza, David Wong, Ago Ahene, Kenneth Der, Zachary Martinez, John Pham, Ronald R. Cobb, Shauna Farr-Jones, James. D. Marks, Milan T. Tomic   +9 more
doaj   +1 more source

The development of immunoassays for the detection of bovine brucellosis and aflatoxin B1 [PDF]

, 2004
The research discussed in this thesis focuses on the development and characterisation of immunoassays for the detection of aflatoxin Bi (AFBi), a toxic fungal metabolite, and for the diagnosis of bovine brucellosis, a highly contagious disease of cattle ...
Dunne, Lynsey
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Cytophilic Antibodies to Plasmodium Falciparum Glutamate Rich Protein are Associated with Malaria Protection in an Area of Holoendemic Transmission. [PDF]

, 2005
Several studies conducted in areas of medium or low malaria transmission intensity have found associations between malaria immunity and plasma antibody levels to glutamate rich protein (GLURP).
Thor G Theander, Theisen, Michael, Martha M Lemnge, Mmbando, Bruno P, Mmbando Bruno P, Kitua, Andrew Y, Lemnge Martha M, Lemnge, Martha M, Theander, Thor G, Andrew Y Kitua, Vestergaard Lasse S, Lasse S Vestergaard, Alifrangis Michael, Theander Thor G, Bruno P Mmbando, Theisen Michael, Vestergaard, Lasse S, Kitua Andrew Y, Lusingu, John P A, Lusingu John PA, Michael Alifrangis, Alifrangis, Michael, Michael Theisen, John PA Lusingu   +23 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Production and Purification of Polyclonal Antibody against Cholera Toxin

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Cholera is a debilitating enteric disease, caused by Vibrio cholerae. Cholera toxin is the most important virulence factor in the pathogenesis of Vibrio cholera.
Shahram Nazarian, Mohammadali Arefpour, Mohammadjavad Bagheripour, gholamreza Olad   +3 more
doaj  

Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]

, 2014
Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V., Diakité, Mahamadou, Felger, Ingrid, Servis, Catherine, Corradin, Giampietro, D’Alessandro, Alba, Moret, Remy, Balam, Saidou, Nebie, Issa, Kajava, Andrey V, Spertini, François, Olugbile, Sope, Smith, Thomas, D'Alessandro, Alba, Frank, Geraldine, Tanner, Marcel   +15 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source