Results 141 to 150 of about 12,464 (172)
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Recombinant BCG therapy suppresses melanoma tumor growth
Annals of Surgical Oncology, 1995Melanoma is the fastest rising cancer in the United States. Bacillus Calmette-Guerin (BCG) has been genetically engineered to actively express and secrete the cytokine interleukin-2 (IL-2). Both BCG and IL-2 have known potent antitumor and immunomodulatory properties.This recombinant BCG (rBCG 3A) has been tested as an intratumoral injection and a ...
R B, Duda +3 more
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Gene replacement by homologous recombination in Mycobacterium bovis BCG
Molecular Microbiology, 1995SummaryGene replacement by homologous recombination is a powerful tool for fundamental studies of gene function, as well as allowing specific attenuation of pathogens, but has proved difficult to achieve for Mycobacterium tuberculosis. We have used a plasmid‐based test system to demonstrate the occurrence of homologous recombination in the tuberculosis
Norman, Elizabeth +3 more
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Recombinant BCG as an antigen delivery system.
Cellular and molecular biology (Noisy-le-Grand, France), 1994BCG, an attenuated vaccine strain of Mycobacterium bovis, has been engineered for use as an antigen delivery vehicle. Various genetic and molecular biological techniques were recently developed for use in the manipulation of mycobacteria. Vectors for the expression of foreign antigens in BCG have been constructed and used to express genes from bacteria,
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Efficacy and safety of live recombinant BCG vaccines.
Developments in biological standardization, 1995BCG has a long history of safe use in humans and is one of the best adjuvants known. The use of newer production methods may further reduce the risk of adverse side-effects. Early results with experimental animals have shown BCG to be an effective live recombinant delivery vehicle for several foreign vaccine antigens.
M S, Hanson +4 more
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Development and Analysis of Recombinant BCG Vector Systems
AIDS Research and Human Retroviruses, 1992T R, Fuerst +3 more
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Use of Recombinant BCG as a Vaccine Delivery Vehicle
1992C K, Stover +6 more
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Development of a BCG Recombinant Vehicle for Candidate AIDS Vaccines
International Reviews of Immunology, 1990A, Aldovini, R A, Young
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BCG as a Vector for the Construction of Multivalent Recombinant Vaccines
Biologicals, 1995openaire +2 more sources