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Frontiers in Bioengineering and Biotechnology, 2019 Infectious diseases, along with cancers, are among the main causes of death among humans worldwide. The production of therapeutic proteins for treating diseases at large scale for millions of individuals is one of the essential needs of mankind.
Nagesh K. Tripathi, Ambuj Shrivastava
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Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity [PDF]
Iranian Journal of Immunology, 2023 Background: Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 receptor (HER2) cell surface antigen overexpressed in approximately 20% of human breast carcinomas. Despite its positive therapeutic
Soodabeh Shafiee +5 more
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HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors
Frontiers in Bioengineering and Biotechnology, 2021 Animal cell-based expression platforms enable the production of complex biomolecules such as recombinant proteins and viral vectors. Although most biotherapeutics are produced in animal cell lines, production in human cell lines is expanding.
Evan Tan +3 more
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Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi +3 more
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Maximizing the Production of Recombinant Proteins in Plants: From Transcription to Protein Stability
International Journal of Molecular Sciences, 2022 The production of therapeutic and industrial recombinant proteins in plants has advantages over established bacterial and mammalian systems in terms of cost, scalability, growth conditions, and product safety.
Ziru Feng +4 more
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Frontiers in Plant Science, 2021 The increase in the world population, the advent of new infections and health issues, and the scarcity of natural biological products have spotlighted the importance of recombinant protein technology and its large-scale production in a cost-effective ...
Ashwini Malla +3 more
semanticscholar +1 more source
Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk
Cancer Cell International, 2022 As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman +9 more
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MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy
Cancer Cell International, 2022 Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC).
Aysooda Hosseinzadeh +4 more
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Journal of Biological Engineering, 2021 Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells.
Mitra Samadi +9 more
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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
Cancer Cell International, 2022 Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors ...
Rana Vafaei +6 more
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