Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential [PDF]
Biophys. J. 87:4021-4035 (2004), 2004 Recognition and binding of specific sites on DNA by proteins is central for many cellular functions such as transcription, replication, and recombination. In the process of recognition, a protein rapidly searches for its specific site on a long DNA molecule and then strongly binds this site.
arxiv +1 more source
Diverse CD81 proteins support hepatitis C virus infection. [PDF]
, 2006 Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a determinant of HCV host range, we expressed a panel of diverse CD81 proteins and tested their ability to interact with HCV.
Balfe, Peter +7 more
core +2 more sources
Blueprint for a high-performance biomaterial: full-length spider dragline silk genes. [PDF]
, 2007 Spider dragline (major ampullate) silk outperforms virtually all other natural and manmade materials in terms of tensile strength and toughness. For this reason, the mass-production of artificial spider silks through transgenic technologies has been a ...
Ayoub, Nadia A +4 more
core +8 more sources
Simultaneous immunization with Omp25 and L7/L12 provides protection against brucellosis in mice [PDF]
, 2020 Currently ...
Aggarwal, Somya +4 more
core +2 more sources
Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective.
Mohammad Doosti +4 more
doaj +1 more source
ExpressInHost: A codon tuning tool for the expression of recombinant proteins in host microorganisms [PDF]
arXiv, 2021 ExpressInHost (https://gitlab.com/a.raguin/expressinhost) is a GTK/C++ based user friendly graphical interface that allows tuning the codon sequence of an mRNA for recombinant protein expression in a host microorganism. Heterologous gene expression is widely implemented in biotechnology companies and academic research laboratories.
arxiv
Rational tangle surgery and Xer recombination on catenanes [PDF]
Algebr. Geom. Topol. 12 (2012) 1183-1210, 2011 The protein recombinase can change the knot type of circular DNA. The action of a recombinase converting one knot into another knot is normally mathematically modeled by band surgery. Band surgeries on a 2-bridge knot N((4mn-1)/(2m)) yielding a (2,2k)-torus link are characterized.
arxiv +1 more source
Tumor Biology, 2017 Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival rate of patients have made triple-negative breast cancer to be considered as the most lethal ...
Behrad Darvishi +3 more
doaj +1 more source
Simplifying recombinant protein production: Combining Golden Gate cloning with a standardized protein purification scheme [PDF]
arXiv, 2023 Recombinant protein production is pivotal in molecular biology, enabling profound insights into cellular processes through biophysical, biochemical, and structural analyses of the purified samples. The demand for substantial biomolecule quantities often presents challenges, particularly for eukaryotic proteins.
arxiv
Computational protein design with evolutionary-based and physics-inspired modeling: current and future synergies [PDF]
, 2022 Computational protein design facilitates discovery of novel proteins with prescribed structure and functionality. Exciting designs were recently reported using novel data-driven methodologies that can be roughly divided into two categories: evolutionary-based and physics-inspired approaches.
arxiv +1 more source