Results 11 to 20 of about 516,295 (311)
Therapeutic recombinant protein production in plants: Challenges and opportunities [PDF]
Plants, People, Planet, 2020 Societal Impact Statement Therapeutic protein production in plants is an area of great potential for increasing and improving the production of proteins for the treatment or prevention of disease in humans and other animals.
Matthew J. B. Burnett, Angela C. Burnett
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Clinical development of therapeutic recombinant proteins [PDF]
BioTechniques, 2003 Only a small subset of the therapeutics that enter clinical studies will prove to be safe and effective in humans and gain approval for marketing. The success of the products and, by inference, the sponsoring companies can be measured by tracking advancement through the clinical phase and review transitions to marketing approval.
Janice M. Reichert, Cherie Paquette
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Bioluminescent monitoring of recombinant lactic acid bacteria and their products
mBio, 2023 Biotherapeutic strategies to promote health, including the application of engineered microbes to deliver therapeutic molecules, hold strong promise. However, without precision tools to detect therapeutic microbes and their products, we are hampered in ...
In Young Choi +3 more
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Pharmaceuticals, 2021 Correct glycosylation of proteins is essential for production of therapeutic proteins as glycosylation is important for protein solubility, stability, half-life and immunogenicity.
Sacha Zeerleder +9 more
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Therapeutic uses of recombinant complement protein inhibitors [PDF]
Springer Seminars in Immunopathology, 1994 In conclusion, it is apparent that researchers are poised at the threshold of developing inhibitors of complement activation from the molecules in the RCA family. By creating soluble forms of these protective proteins for in vivo administration, or by making transgenic animals expressing these proteins or their derivatives, it may be possible to ...
Kalli, Kimberly R. +2 more
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Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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Arabinosylation of recombinant human immunoglobulin-based protein therapeutics [PDF]
mAbs, 2017 Protein glycosylation is arguably the paramount post-translational modification on recombinant glycoproteins, and highly cited in the literature for affecting the physiochemical properties and the efficacy of recombinant glycoprotein therapeutics. Glycosylation of human immunoglobulins follows a reasonably well-understood metabolic pathway, which gives
Hossler, Patrick +13 more
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Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]
, 2015 BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu +3 more
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The Effects of the Recombinant CCR5 T4 Lysozyme Fusion Protein on HIV-1 Infection. [PDF]
PLoS ONE, 2015 Insertion of T4 lysozyme (T4L) into the GPCR successfully enhanced GPCR protein stability and solubilization. However, the biological functions of the recombinant GPCR protein have not been analyzed.We engineered the CCR5-T4L mutant and expressed and ...
Qingwen Jin +10 more
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Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]
, 2015 MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M. +8 more
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